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    1. Neuroscience
    2. Physics of Living Systems

    “What” × “When” working memory representations using Laplace Neural Manifolds

    Aakash Sarkar, Shangfu Zuo ... Marc W Howard
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology

    Concatenated modular BK channel constructs reveal divergent stoichiometry in gating control by LRRC26 (γ1), pore, and selectivity filter

    Guanxing Chen, Qin Li ... Jiusheng Yan
    Regulatory stoichiometry in large-conductance potassium (BK) channels diverges by mechanism, separating single-subunit activation, graded pore contributions, and collective selectivity-filter control.
    1. Neuroscience

    High-fidelity neural speech reconstruction through an efficient acoustic-linguistic dual-pathway framework

    Jiawei Li, Chunxu Guo ... Yuanning Li
    Concurrent decoding of acoustic detail and linguistic structure enables natural, intelligible speech synthesis from limited human cortical recordings, resolving a fundamental constraint in neural speech reconstruction.
    1. Cell Biology

    Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

    Qian Lyu, Qingchao Li ... Huijie Zhao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Developmental Biology
    2. Neuroscience

    Developmental sleep reallocation enables metabolic adaptation in desert flies

    Shuhao Li, Milan Szuperak ... Matthew S Kayser
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    A high-throughput assay for the measurement of Ca2+-oscillations and insulin release from uniformly sized β-cell spheroids

    Stijn Robben, Patricia Davidson ... Thomas Voets
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Material Damage to Multielectrode Arrays after Electrolytic Lesioning is in the Noise

    Alice Tor, Stephen E Clarke ... Brain Interfacing Laboratory
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Developmental Biology

    Primordial cardiomyocytes orchestrate myocardial morphogenesis and vascularization but are dispensable for regeneration

    Jisheng Sun, Lu Chen, Jinhu Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    Fine-tuning of outer membrane–peptidoglycan tethering by the redox-active lipoprotein LppB from Salmonella enterica

    Elisa S Pierre Despas, Seung-Hyun Cho ... Jean-François Collet
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Solid
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