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Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets of Hedgehog pathway activity.

Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.

Gaseous CO₂ acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.

A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and intuitive diagnostics.

Minimally disruptive genetic code expansion enables faithful, site-specific labeling of G3BP1 and TDP-43, revealing native stress granule dynamics and ALS-linked protein behavior in live cells.

This article provides critical insights in guiding aspiring physician-scientist medical students on how to choose a clinical specialty.