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    1. Developmental Biology
    2. Neuroscience

    Afadin sorts different retinal neuron types into accurate cellular layers

    Matthew R Lum, Sachin Patel ... Xin Duan
    Genetic perturbation of Afadin in the retina reveals its importance for the precise organization of the retinal layers while leaving neuronal fate and numbers unaffected.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Computational and Systems Biology

    Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

    Júlia Domingo, Mariia Minaeva ... Tuuli Lappalainen
    A new CRISPR-based approach for tuning gene expression up and down allowed identification of how other genes' expression responds to changes of transcription factors.
    1. Genetics and Genomics

    The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype

    Feroz Akhtar, Joselin Hernandez Ruiz ... Srinivas Mummidi
    Bioinformatics, RNA-protein interactions, and HuR-based functional studies demonstrated that the rs13900T allele modulates CCL2 transcript levels, providing a functional link between the CCL2 rs1024611G-rs13900T haplotype and disease susceptibility/progression.
    1. Neuroscience

    Prefoldin 5 is a microtubule-associated protein that suppresses Tau aggregation and neurotoxicity

    Anjali Bisht, Srikanth Pippadpally ... Vimlesh Kumar
    Prefoldin 5 stabilises neuronal microtubules and suppresses Tau-mediated neurotoxicity, offering a potential therapeutic target for tauopathies.
    1. Cell Biology

    MIRO1 controls energy production and proliferation of vascular smooth muscle cells

    Lan Qian, Olha M Koval ... Isabella M Grumbach
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Enhanced Processivity and Collective Force Production of Kinesin-1 at Low Radial Forces

    Andrew M Hensley, Ahmet Yildiz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Developmental Biology
    2. Computational and Systems Biology

    A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

    Alice Gros, Jules Vanaret ... Sham Tlili
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    The oneirogen hypothesis: modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms

    Colin Bredenberg, Fabrice Normandin ... Guillaume Lajoie
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Convincing
    1. Medicine
    2. Neuroscience

    Impaired Adaptive Learning in Chronic Pain Contributes to Apathy

    Xinyuan Yan, Crina M Peterson ... David P Darrow
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Neural correlates of perceptual consciousness from within: a narrative review of human intracranial research

    Francois Stockart, Alexis Robin ... Nathan Faivre
    Not revised
    Reviewed Preprint v1
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