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    1. Structural Biology and Molecular Biophysics

    Active regulation of the epidermal growth factor receptor by the membrane bilayer

    Shwetha Srinivasan, Xingcheng Lin ... Gabriela S Schlau-Cohen
    Membrane composition modulates EGFR conformational dynamics and signaling, revealing that the bilayer properties can override ligand control to influence receptor activation in health and disease.
    1. Cell Biology

    Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch

    Shivam Shukla, Jessica A Cross ... Mark P Dodding
    Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects cargo recognition to motor activation.
    1. Neuroscience
    2. Evolutionary Biology

    Three-dimensional and molecular brain atlas of the hagfish reveals the evolutionary origin and early diversification of the vertebrate brain

    Riho Harada, Motoki Tamura ... Daichi G Suzuki
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Medicine
    2. Neuroscience

    Evaluating biomarkers and prediction models with E2P Simulator

    Povilas Karvelis, Daniel Felsky ... Andreea O Diaconescu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    REM sleep prefrontal high-frequency oscillation chains mediate distinct cortical – hippocampal reactivation patterns compared to NREM sleep

    Justin D Shin, Michael Satchell ... Shantanu P Jadhav
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Individuality across environmental context in Drosophila melanogaster

    Thomas F Mathejczyk, Cara Knief ... Gerit A Linneweber
    Environmental differences alter behavioral performance in Drosophila melanogaster without eliminating consistent individual differences.
    1. Neuroscience

    Audiovisual cues must be predictable and win-paired to drive risky choice

    Brett A Hathaway, Dexter R Kim ... Catharine Winstanley
    Sensory cues increase risky choice when paired with wins but reduce risky choice when paired with losses, with parallel shifts in sensitivity to negative outcomes.
    1. Neuroscience

    Preserved cerebellar functions despite structural degeneration in older adults

    Anda de Witte, Anouck Matthijs ... Jean-Jacques Orban de Xivry
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Gene synteny and translational coupling of sctS and sctT facilitate assembly of the unique helical T3SS export apparatus in Salmonella Typhimurium

    Eunjin Kim, Mirjam Forberger ... Samuel Wagner
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology

    MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

    Yibing Bao, Zhenzi Zuo ... Chao Wang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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