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    1. Neuroscience

    Method of loci training yields unique prefrontal representations that support effective memory encoding

    Jingyuan Ren, Boris N Konrad ... Isabella C Wagner
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics
    2. Evolutionary Biology

    The causes and consequences of human-specific DNA methylation

    Zhenzhen Ma, Alexander L Starr ... Hunter B Fraser
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interrogating the structure and function of the human voltage-gated proton channel (hHv1) with a fluorescent noncanonical amino acid

    Emerson M Carmona, William N Zagotta, Sharona E Gordon
    A fluorescent noncanonical amino acid enables structural measurements across full-length human voltage-gated proton channel (Hv1) and reveals zinc-dependent conformational changes.
    1. Evolutionary Biology

    Inference of germinal center evolutionary dynamics via simulation-based deep learning

    Duncan K Ralph, Athanasios G Bakis ... Frederick A Matsen
    Deep learning applied to B cell phylogenies reveals a simple, measurable curve relating receptor affinity to evolutionary fitness in germinal centers.
    1. Neuroscience

    Behavioral Signatures of Post-Decisional Attention in Preferential Choice

    Ariel Zylberberg, Ian Krajbich, Michael N Shadlen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease

    Joshua K Morrison, Ksenija Sabic ... Ling-shiang Chuang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Arrayed single-gene perturbations identify drivers of human anterior neural tube closure

    Roya E Huang, Giridhar M Anand ... Sharad Ramanathan
    Revised
    Reviewed Preprint v2
    Updated
    • Landmark
    • Exceptional
    1. Medicine
    2. Neuroscience

    A non-human primate model of Amyotrophic Lateral Sclerosis

    Rachael HA Jones, Luciano Saieva ... Stuart N Baker
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

    Shan Zhang, Robyn Stix ... José D Faraldo-Gómez
    Computer simulations reveal the structural basis for a selective mechanism of ion-channel inhibition that could guide future pharmacological developments against associated human health disorders.
    1. Neuroscience

    AFD thermosensory neurons mediate tactile-dependent locomotion modulation in C. elegans

    Manuel Rosero, Jihong Bai
    The thermosensory neuron AFD unexpectedly modulates locomotion based on tactile experience through molecular and circuit mechanisms distinct from those underlying thermosensation.
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