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Page 62 of 1,858
    1. Cancer Biology
    2. Cell Biology

    Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

    Qi Zhang, Yunfeng Wang ... Shaowei Zhao
    Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.
    1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding specificity and compaction of DNA

    Dillon E King, Emily E Beard ... Joel Meyer
    Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
    1. Immunology and Inflammation

    During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics

    Kaylee SE van Dijk, Christina Begon-Pescia ... Maria Forlenza
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology

    Chromatin priming and Hunchback recruitment integrate spatial and temporal cues in Drosophila neuroblasts

    Ayanthi Bhattacharya, Hemalatha Rao, Sonia Q Sen
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    • Solid
    1. Medicine

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

    Naci Oz, Hetian Su ... Alaattin Kaya
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The spike tip protein of bacteriophage T4

    Yves Mattenberger, Ekaterina S Knyazhanskaya ... Dominique Belin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Neuroscience

    Visual information is broadcast among cortical areas in discrete channels

    Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith
    Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
    1. Neuroscience
    2. Physics of Living Systems

    A deep learning pipeline for mapping in situ network-level neurovascular coupling in multi-photon fluorescence microscopy

    Matthew W Rozak, James R Mester ... Bojana Stefanovic
    A novel pipeline for analyzing longitudinal two-photon microscopy data of cerebrovasculature in mice interrogates the vasculature network before and after optogenetic stimulation, revealing new insights into their coordination.
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