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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Effects of residue substitutions on the cellular abundance of proteins

    Thea K Schulze, Kresten Lindorff-Larsen
    Empirical substitution matrices from experimental measurements on 31,614 variants accurately predict cellular protein abundance changes using only amino-acid substitution and whether the site is buried or exposed.
    1. Cell Biology

    SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection

    Curdin A Franziscus, Alexia Ferrand ... Anne Spang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

    Chiara Asselborn, Agata N Makar ... Alexander von Kriegsheim
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Cancer cells differentially modulate mitochondrial respiration to alter redox state and enable biomass synthesis in nutrient-limited environments

    Sarah M Chang, Muhammad Bin Munim ... Matthew G Vander Heiden
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

    Elise J Meijer, Marissa Mueller ... Zoltán Molnár
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Computational and Systems Biology

    High-frequency spike inference with particle Gibbs sampling

    Giovanni Diana, B Semihcan Sermet ... David A DiGregorio
    A Bayesian particle Gibbs framework enables unbiased spike time inference with millisecond resolution and jointly estimates uncertainties in both spike timing and model parameters from fast calcium imaging.
    1. Cell Biology

    Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle control

    Thomas Moss, Alexandra Wooldredge ... Shaeri Mukherjee
    A phosphorylation site on Hsp70 previously linked to pathogen activity functions endogenously in DNA damage responses and connects chaperone regulation to cell cycle control.
    1. Structural Biology and Molecular Biophysics

    Two Glu/Asp Residues Cooperatively Mediate an Early Step of ATP Hydrolysis in GHKL ATPases MutL and GyrB

    Kenji Fukui, Ayaka Shibuya ... Takato Yano
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Neuroscience

    Loose coupling between Ca2+ channels and release sensors as a synaptic correlate of higher order brain function

    Max Schwarze, Grit Bornschein ... Hartmut Schmidt
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
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