Marie Baldenius, Steffen Kautzmann ... Christian Klämbt
In Drosophila larva, the Uninflatable protein helps to switch from FGF-receptor triggered glial growth to Notch triggered wrapping of peripheral axons.
Inhibiting PRMT1 and PRMT5 renders HR-proficient ovarian and breast cancers highly vulnerable to PARP inhibition by suppressing BRCAness and amplifying DNA-damage-driven innate immune signaling.
Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.