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Coregulator TR-FRET profiling reveals ligand-specific LXR signaling signatures that can guide the therapeutic design of ABCA1-inducing LXR agonists with attenuated risk of hepatic lipogenesis.

CLas hijacks the DA/DcDop2-miR-31a-AKH-JH signaling cascade to improve D. citri lipid metabolism and fecundity, while simultaneously promoting its replication.

Chemogenetic and in vivo recording approaches reveal how persistent hyperactivity in the posterior paraventricular thalamus promotes sensitization of fear responses to unlearned threats after stress exposure.

Single-neuron recordings reveal that anterior cingulate cortex and caudate nucleus encode the interaction between rewards, state transitions, and choices that underlies flexible, goal-directed decision-making.

A review of literature regarding trained immunity (TI) differentiates two distinct stages of metabolic immune regulation, with primary metabolic changes influencing early epigenetic adaptations that drive TI induction and secondary metabolic adaptations providing building blocks required for enhanced immune function.

Tunable Bessel beam two-photon fluorescence microscopy enables high-speed volumetric intravital imaging of subcellular dynamics within living mouse brains with fully tunable spatial resolution and volume coverage, allowing flexible sampling and measurements of vascular, neuronal, and immune dynamics.

Long-term motor recovery after musculoskeletal alteration relies on gradually developing novel compensatory movements to overcome the rigid, maladaptive timing of stable muscle synergies.

Esr1 directs adolescent transcriptional maturation of medial preoptic GABAergic neurons, enabling the normal development of mating behavior in male and female mice.

An analysis of the largest publicly available collection of scanning electron microscopy images of explanted multielectrode arrays reveals that electrolytic lesioning causes no significant additional damage to array electrodes.