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    1. Developmental Biology

    ANKEF1 is a key axonemal component essential for murine sperm motility and male fertility

    Shuntai Yu, Guoliang Yin ... Fengchao Wang
    ANKEF1 stabilizes the sperm axoneme by reinforcing the nexin–dynein regulatory complex, revealing a mechanical buffering mechanism essential for flagellar integrity and male fertility.
    1. Microbiology and Infectious Disease

    A system for functional studies of the major virulence factor of malaria parasites

    Jakob Cronshagen, Johannes Allweier ... Tobias Spielmann
    The generation of malaria parasites expressing only one of the multiple variants of their most important virulence factor enables the study of different aspects of this virulence factor.
    1. Cancer Biology

    Sex differences in bile acid homeostasis and excretion underlie the disparity in liver cancer incidence between males and females

    Megan E Patton, Sherwin Kelekar ... Sayeepriyadarshini Anakk
    Transcriptomic and metabolite analysis reveal sex differences in circulation and excretion of bile acids in a mouse- model of hepatocellular carcinoma (HCC), and the identified female-specific gene profile correlates with better HCC survival.
    1. Immunology and Inflammation

    Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production

    Conan JO O'Brien, Giorgio Ratti ... Ana I Domingos
    Loss of class A scavenger receptor MARCO results in elevated lung Ace expression and elevated plasma aldosterone concentrations in male mice, demonstrating an endocrine function of this immune scavenger receptor.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection

    Alina Xiaoyu Yang, Lisa Ramos-Rodriguez ... Yang Zhou
    PLSCR1 is an IFN-λ-stimulated gene that enhances IFN-λR1 expression at both transcriptional and protein level, highlighting the potential for targeting PLSCR1 pathways in anti-influenza therapy.
    1. Structural Biology and Molecular Biophysics

    Nucleosome wrapping energy in CpG islands and the role of epigenetic base modifications

    Rasa Giniūnaitė, Rahul Sharma ... Daiva Petkevičiūtė-Gerlach
    CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.
    1. Neuroscience

    Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

    Louis Richevaux, Dongkyun Lim ... Desdemona Fricker
    Nonlinear dendritic integration in single presubicular neurons provides a mechanism for combining vestibular-based head-direction signals and visual landmark signals to anchor the brain’s internal compass.
    1. Neuroscience

    Daily life fluctuations in affect predict within-person changes in a real-world measure of cognitive processing speed

    Sol Fittipaldi, Vanessa Teckentrup ... Claire M Gillan
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Enteropathogenic E. coli-mediated Fast and Coordinated Ca²⁺ responses regulate NF-κB activation

    Fangrui Guo, Roberto Ornelas Guevara ... Guy Tran Van Nhieu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology

    Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans

    Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Solid