Browse our latest research

Page 62 of 1,876
    1. Medicine

    Hyperactivated glycolysis drives spatially patterned Kupffer cell depletion in MASLD

    Jia He, Ran Li ... Zhao Shan
    Glycolytic activation directly drives Kupffer cell loss in early metabolic dysfunction-associated steatotic liver disease, highlighting a targetable metabolic vulnerability.
    1. Neuroscience

    Inhibitory columnar feedback neurons are involved in motion processing in Drosophila

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Inhibitory GABAergic feedback neurons tune direction-selective motion signals in Drosophila, sharpening behavioral responses to rapidly changing visual stimuli and expanding canonical feedforward models of visual motion computation.
    1. Ecology
    2. Physics of Living Systems

    Cognitive simplicity drives collective route improvements in homing pigeons

    Shoubhik Chandan Banerjee, Fritz A Francisco, Albert B Kao
    A navigational model exploring social learning strategies differing in cognitive complexity in homing pigeons shows that simple averaging sufficiently explains collective route improvements, without requiring cumulative cultural evolution.
    1. Neuroscience

    Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

    Jixing Li, Qixuan Wang ... Zhiwu Huang
    Hearing impairment selectively disrupts neural tracking of speech at both short and long temporal scales during multi-speaker listening, while preserving intermediate linguistic processing.
    1. Cell Biology

    Syntaxin11 Deficiency Inhibits CRAC Channel Priming to Suppress Cytotoxicity and Gene Expression in T Lymphocytes

    Sritama Datta, Abhikarsh Gupta ... Monika Vig
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Endocardial TIE1 synergizes with TIE2 to regulate the atrial internal muscular network assembly

    Kai Ding, Beibei Xu ... Yulong He
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Physics of Living Systems

    An engineered multi-step differentiation program in Escherichia coli for self-organized spatial patterning

    Emanuele Boni, Hélène Siboulet ... Yolanda Schaerli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative pipeline for whole-mount deep imaging and analysis of multi-layered organoids across scales

    Alice Gros, Jules Vanaret ... Sham Tlili
    The Tapenade pipeline enables single-cell, whole-mount 3D quantification in dense multilayer organoids, linking spatial gene co-expression and nuclear deformation to emerging tissue-scale organization.
    1. Biochemistry and Chemical Biology

    Isolation of small extracellular vesicles from small volumes of blood plasma using size exclusion chromatography and density gradient ultracentrifugation

    Fang Kong, Megha Upadya ... Ming Dao
    The optimized protocol for isolating small extracellular vesicles from small blood volumes, confirmed by independent methods including cryo-electron microscopy, ensures superior purity and high yield for reliable biomarker detection.
    1. Developmental Biology
    2. Genetics and Genomics

    In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation

    Gustavo Aguilar, Michèle E Sickmann ... Martin Müller
    Early enhancer logic precisely aligns developmental boundaries by integrating HOX, GATA, and signaling inputs, ensuring correct tissue patterning and preventing mirror-image duplications in the developing wing.