Physical gel models and numerical simulations have been created to study ferret brain gyrification and cortical malformations, while comparisons with human phenotypes aim to link genetics and brain morphogenesis.
Maintaining CDK4/6 inhibition constrains drug‑resistant breast tumors by delaying cell‑cycle entry, and adding CDK2 inhibition further deepens control to guide post‑progression therapy.
Post‑HI oxidative‑phosphorylation uncoupling drives secondary energy failure in neonatal brains, and preventing the post‑HI CMRO2 surge is a key mechanism underlying hypothermia’s neuroprotection.
