Diet-induced obesity, insulin resistance, and proinflammatory macrophage activation and accumulation in adipose tissue can be counteracted through the inhibition of ER stress sensor IRE1alpha.
Dharmendra Kumar Nath, Subash Dhakal, Youngseok Lee
TRPγ is essential for maintaining lipid homeostasis in Drosophila melanogaster, linking neuronal regulation to fat metabolism and suggesting potential therapeutic avenues for metabolic disorders.
Chitons overcome evolutionary constraints through unprecedented genomic dynamism, with extensive chromosomal rearrangements and duplications despite about 300 million years of morphological stasis.
Kinetic measurements of kinesin-1's front and rear heads reveal how different neck linker orientation regulate their activity, enabling the motor protein to move in a coordinated manner along microtubules.
