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Page 717 of 1,750
    1. Developmental Biology

    Visually induced changes in cytokine production in the chick choroid

    Jody A Summers, Elizabeth Martinez
    IL-6 gene and protein expression are rapidly and transiently upregulated in the choroid in response to myopic defocus, as a result of prior form deprivation or treatment with +15 D lenses in a nitric oxide-dependent manner.
    1. Neuroscience

    Live imaging reveals the cellular events downstream of SARM1 activation

    Kwang Woo Ko, Laura Devault ... Aaron DiAntonio
    Axon degeneration occurs via an ordered sequence of events downstream of SARM1 that proceeds from ATP loss, to defects in mitochondrial movement and depolarization, followed by calcium influx, phosphatidylserine externalization, loss of membrane permeability, and ending with catastrophic axonal self-destruction.
    1. Neuroscience

    The decoy SNARE Tomosyn sets tonic versus phasic release properties and is required for homeostatic synaptic plasticity

    Chad W Sauvola, Yulia Akbergenova ... J Troy Littleton
    Loss of the decoy SNARE Tomosyn enhances synaptic vesicle docking and neurotransmitter release and regulates release and plasticity differences between tonic and phasic motoneurons in Drosophila.
    1. Genetics and Genomics

    Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast

    Alaattin Kaya, Cheryl Zi Jin Phua ... Vadim N Gladyshev
    Analysis of molecular signatures of lifespan variation across wild yeast isolates revealed how Nature employs environment to modify genotype, gene expression, and metabolome to arrive at different lifespan, while preserving fitness in various ecological niches.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

    Xiao-Man Liu, Liang Ma, Randy Schekman
    Condensation of cytosolic protein YBX1 into processing bodies reveals mechanisms for efficient and selective sorting of proteins and their cognate microRNAs into exosomes.
    1. Cell Biology
    2. Medicine

    Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots

    Kathryn P Trogden, Justin Lee ... Irina Kaverina
    Analysis of insulin secretion patterns in pancreatic islets shows that microtubules control β-cell heterogeneity by regulating initiation and timing of secretion hot spot activity in parallel with Ca2+ signaling.
    1. Microbiology and Infectious Disease

    The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health

    Qi Yan Ang, Diana L Alba ... Peter J Turnbaugh
    The gut microbiota of East Asians is distinct, dissociated from body mass, and self-sustains compared to White subjects from the same region, and therein may underpin a key health disparity.
    1. Cell Biology
    2. Medicine

    An experimental test of the effects of redacting grant applicant identifiers on peer review outcomes

    Richard K Nakamura, Lee S Mann ... Bruce Reed
    Redaction, intended to obscure personal and institutional identity, reduced the gap between Black vs. White applicants in simulated review of real NIH scientific grant applications, thus providing qualified support for double-blinded models of peer review.
    1. Neuroscience

    Distinct dendritic Ca2+ spike forms produce opposing input-output transformations in rat CA3 pyramidal cells

    Ádám Magó, Noémi Kis ... Judit K Makara
    Dendritic patch-clamp recordings combined with two-photon imaging and glutamate uncaging reveal two types of regenerative calcium spikes in the dendrites of CA3 pyramidal neurons from rat hippocampus.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response

    Amelia E Hinman, Charul Jani ... Amy K Barczak
    The pathogenic success of Mycobacterium tuberculosis relies in part on its ability to blunt a component of the TLR2-dependent immune response.