Nathaniel R Braffman, Terry B Ruskoski ... Emily P Balskus
The X-ray crystal structure of the unusual carbon–carbon bond-forming biosynthetic enzyme CylK reveals a unique biochemical strategy for selective alkyl halide activation and substitution.
TADR (torn and diminished rhabdomeres)-dependent histidine transporting is required for de novo synthesis of histamine and for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
Tobias J Buscham, Maria A Eichel-Vogel ... Hauke B Werner
When oligodendrocytes lack expression of the low-abundant myelin protein CMTM5, central nervous system axons are myelinated normally but subsequently degenerate involving a Wallerian-like pathomechanism.
Deep mutagenesis experiments demonstrate that while cancer-causing mutations in Ras selectively alter regulatory interactions with GTPase-activating proteins, Ras is also activated by many mutations that decrease protein stability.
Stimulus-induced causal interactions in the gamma range can flow in direction opposite to the canonical microcircuit, violating the notion that they are signatures of feedforward communication.
Meaghan Castledine, Daniel Padfield ... Angus Buckling
Parallel evolutionary dynamics were found in vivo and in vitro, showing that laboratory studies can be predictive of certain phenotypic outcomes of clinical phage therapy (phage-mediated decolonization).
SPRRs are bactericidal proteins, stimulated in the sebaceous gland by lipopolysaccharide, that defend the host against infection through bacterial membrane binding and disruption.
Humans perseverate on previously instructed goals in a novel multigoal reinforcement learning task, and do this to a greater extent for punishment avoidance goals.
