Browse our latest research

Page 8 of 1,734
    1. Neuroscience

    An anatomical and physiological basis for flexible coincidence detection in the auditory system

    Lauren J Kreeger, Suraj Honnuraiah ... Lisa Goodrich
    In the mammalian auditory brainstem, inhibitory inputs onto octopus cell dendrites enhance coincidence detection computations and support precise yet flexible temporal processing for rapid sound onsets and frequency modulations.
    1. Cell Biology
    2. Immunology and Inflammation

    UFMTrack, an Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

    Mykhailo Vladymyrov, Luca Marchetti ... Britta Engelhardt
    The established under-flow migration tracker (UFMTrack) framework allows for automated and scalable studies of immune cell interactions with and extravasation across endothelial monolayer under flow in vitro.
    1. Immunology and Inflammation

    Coevolutionary interplay: Helminths-trained immunity and its impact on the rise of inflammatory diseases

    Eugenio Antonio Carrera Silva, Juliana Puyssegur, Andrea Emilse Errasti
    Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and extracellular vesicles.
    1. Microbiology and Infectious Disease

    Serial ‘deep-sampling’ PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected human, macaque, and canine hosts, and allows accurate monitoring of parasite load following treatment

    Brooke E White, Carolyn L Hodo ... Rick L Tarleton
    A vastly improved PCR-based approach provides a long-sought test of cure and parasite load monitoring tool for Chagas disease.
    1. Structural Biology and Molecular Biophysics

    Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes

    Christopher T Schafer, Raymond F Pauszek III ... David P Millar
    The conformational dynamics and landscapes of the related chemokine receptors CXCR4 and ACKR3, revealed by single-molecule analysis, provide mechanistic insights into differences in constitutive activity, ligand promiscuity, and effector coupling.
    1. Genetics and Genomics

    Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

    Irina Lazar-Contes, Rodrigo G Arzate-Mejia ... Isabelle M Mansuy
    Developmental transitions in mouse spermatogonial cells reveal extensive chromatin remodeling, stage-specific gene expression, and newly accessible transposable elements with regulatory potential.
    1. Medicine

    Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa

    Hyun Beom Song, Laura Campello ... Anand Swaroop
    Reserpine, previously identified through high-throughput screening in CEP290 retinal degeneration models, enhances photoreceptor survival in P23H rhodopsin retinal degeneration models, particularly in female rats, indicating its gene-agnostic and sex-specific effectiveness.
    1. Neuroscience

    Adult Neurogenesis Reconciles Flexibility and Stability of Olfactory Perceptual Memory

    Bennet Sakelaris, Hermann Riecke
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Automatic learning mechanisms for flexible human locomotion

    Cristina Rossi, Kristan A Leech ... Amy J Bastian
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Precise Spatial Tuning of Visually Driven Alpha Oscillations in Human Visual Cortex

    Kenichi Yuasa, Iris IA Groen ... Jonathan Winawer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing