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    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

    Caleb Hallinan, Hyun Joo Ji ... Jean Fan
    Computational assessment identifies probe binding errors in a widely used commercial platform for spatial transcriptomics.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    RadD from Fusobacterium nucleatum engages NKp46 to promote antitumor cytotoxicity

    Ahmed Rishiq, Johanna Galaski ... Ofer Mandelboim
    RadD recognition by NKp46 converts Fusobacterium nucleatum from an immune-evasive pathogen into a trigger of natural killer cell-mediated tumor control in a context-dependent manner.
    1. Genetics and Genomics

    Adapting clinical chemistry plasma as a source for liquid biopsies

    Spencer C Ding, Jingru Yu ... Wei Gu
    Residual plasma from rapid routine clinical chemistry tubes enables cell-free DNA NGS-based analysis, providing an untapped, scalable, and accessible resource without specialized collection workflows.
    1. Neuroscience

    Sexual dimorphism in sensorimotor transformation of optic flow

    Sarah Nicholas, Katja Sporar Klinge ... Karin Nordström
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Growth in early infancy drives optimal brain functional connectivity which predicts cognitive flexibility in later childhood

    Chiara Bulgarelli, Anna Blasi ... BRIGHT Study Team
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Subregional activity in the dentate gyrus is amplified during elevated cognitive demands

    Charlotte CM Castillon, Shintaro Otsuka ... Anis Contractor
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Immunology and Inflammation

    Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

    Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience

    Autonomic reflex plasticity associates with time-dependent SUDEP susceptibility in a murine model with hyperactive stress circuits

    Sandy E Saunders, Kaylie E Dow ... Carie R Boychuk
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Parallel Wires: A Conserved Principle of Contralateral-Ipsilateral Segregation in the Visual Corpus Callosum

    Jiaowen Wang, Yanming Wang ... Xiaoxiao Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity

    Ryo Masumura, Kyosuke Goda ... Naofumi Uesaka
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
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