Mice lacking the secreted hormone, CTRP10, represent a unique female model of obesity with preserved metabolic health, highlighting sex-specific mechanisms that uncouple obesity from metabolic dysfunction.
Hippocampal replay, which is implicated in memory formation and planning, exhibits a reward-dependent spatial specificity that in novel environments requires dopamine signaling.
ORMDL3 promotes RIG-I degradation to suppress type I interferon signaling pathway and antiviral immune response, highlighting ORMDL3 as a potential therapeutic target in viral infection and cancer immunotherapy.