Browse our latest research

Page 908 of 1,761
    1. Neuroscience

    Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

    Iku Tsutsui-Kimura, Hideyuki Matsumoto ... Mitsuko Watabe-Uchida
    Dopamine signals in the ventral, dorsomedial, and dorsolateral striatum are modulated by various variables, such as stimulus-associated value, choice, confidence, but these modulations can be inclusively explained by TD errors.
    1. Neuroscience

    Topographic gradients of intrinsic dynamics across neocortex

    Golia Shafiei, Ross D Markello ... Bratislav Misic
    Intrinsic dynamics are shaped by the intersection of molecular, microstructural, connectomic, and activation gradients.
    1. Plant Biology

    Regulation of shoot meristem shape by photoperiodic signaling and phytohormones during floral induction of Arabidopsis

    Atsuko Kinoshita, Alice Vayssières ... George Coupland
    The shoot meristem becomes domed in shape during floral transition and this is controlled by flowering pathways and the phytohormone gibberellin causing increases in cell size and number.
    1. Cell Biology
    2. Medicine

    Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis

    Zhonghao Deng, Courtney Ng ... Baohong Zhao
    Def6 functions as a novel immunoregulator in bone cells via endogenous type-I interferon response to regulate bone remodeling.
    1. Evolutionary Biology

    Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits

    Melissa L Spear, Alex Diaz-Papkovich ... Ryan D Hernandez
    Admixture dynamics have recently changed over time in Mexican Americans resulting in an impact on the genetic architecture of phenotypic variation.
    1. Neuroscience

    The brain in motion: How ensemble fluidity drives memory-updating and flexibility

    William Mau, Michael E Hasselmo, Denise J Cai
    Ensemble fluidity, observed as synaptic turnover and temporal drift in neuronal patterns, supports memory-updating and flexibility while maintaining memory stability.
    1. Computational and Systems Biology
    2. Neuroscience

    Diverse and complex muscle spindle afferent firing properties emerge from multiscale muscle mechanics

    Kyle P Blum, Kenneth S Campbell ... Lena H Ting
    Diverse muscle spindle firing, critical for a range of sensorimotor behaviors, is compactly explained by first principles of force development in specialized muscle fibers within the sensors.
    1. Cancer Biology

    Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

    Richard Lee Barrett, Ellen Puré
    Long under-appreciated, fibroblast biology is a key aspect of understanding how the immune system responds to tumors and may hold the key to improving immunotherapy in this tricky space.
    1. Neuroscience

    Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction

    Opeyemi O Alabi, M Felicia Davatolhagh ... Marc Vincent Fuccillo
    Disruption of the disease-associated synaptic adhesion molecule Neurexin1a in cortical excitatory neurons perturbs decision making and disrupts value-associated neural activity in downstream striatal circuits.
    1. Plant Biology

    Altered N-glycan composition impacts flagella-mediated adhesion in Chlamydomonas reinhardtii

    Nannan Xu, Anne Oltmanns ... Michael Hippler
    Adhesion force measurements reveal that proper N-glycosylation of flagellar membrane proteins is crucial for adhering C. reinhardtii cells onto surfaces.