1. Evolutionary Biology
  2. Genetics and Genomics
Download icon

Sex-specific transcriptomic responses to changes in the nutritional environment

  1. M Florencia Camus  Is a corresponding author
  2. Matthew DW Piper
  3. Max Reuter
  1. University College London, United Kingdom
  2. Monash University, Australia
Research Article
  • Cited 0
  • Views 971
  • Annotations
Cite this article as: eLife 2019;8:e47262 doi: 10.7554/eLife.47262

Abstract

Males and females typically pursue divergent reproductive strategies and accordingly require different dietary compositions to maximise their fitness. Here we move from identifying sex-specific optimal diets to understanding the molecular mechanisms that underlie male and female responses to dietary variation in Drosophila melanogaster. We examine male and female gene expression on male-optimal (carbohydrate-rich) and female-optimal (protein-rich) diets. We find that the sexes share a large core of metabolic genes that are concordantly regulated in response to dietary composition. However, we also observe smaller sets of genes with divergent and opposing regulation, most notably in reproductive genes which are over-expressed on each sex's optimal diet. Our results suggest that nutrient sensing output emanating from a shared metabolic machinery are reversed in males and females, leading to opposing diet-dependent regulation of reproduction in males and females. Further analysis and experiments suggest that this reverse regulation occurs within the IIS/TOR network.

Article and author information

Author details

  1. M Florencia Camus

    Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
    For correspondence
    f.camus@ucl.ac.uk
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-0626-6865
  2. Matthew DW Piper

    School of Biological Sciences, Monash University, Melbourne, Australia
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0003-3245-7219
  3. Max Reuter

    Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
    Competing interests
    The authors declare that no competing interests exist.
    ORCID icon "This ORCID iD identifies the author of this article:" 0000-0001-9554-0795

Funding

European Commission (#708362)

  • M Florencia Camus

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Reviewing Editor

  1. Laurent Keller, University of Lausanne, Switzerland

Publication history

  1. Received: March 29, 2019
  2. Accepted: August 21, 2019
  3. Accepted Manuscript published: August 22, 2019 (version 1)

Copyright

© 2019, Camus et al.

This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Metrics

  • 971
    Page views
  • 187
    Downloads
  • 0
    Citations

Article citation count generated by polling the highest count across the following sources: Crossref, PubMed Central, Scopus.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)

Further reading

    1. Developmental Biology
    2. Evolutionary Biology
    Lotta Salomies et al.
    Research Article Updated
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease
    Alfonso Santos-Lopez et al.
    Research Article