1. Cancer Biology
Download icon

Reproducibility in Cancer Biology: Rethinking research into metastasis

  1. Peter Friedl  Is a corresponding author
  1. Radboud University Medical Centre, Netherlands
  2. University of Texas MD Anderson Cancer Center, United States
Insight
Cite this article as: eLife 2019;8:e53511 doi: 10.7554/eLife.53511
1 figure

Figures

Studying tumor invasion and metastasis.

(A) The orientation of the extracellular matrix (ECM) and fibroblasts in the vicinity of a tumor (pale blue) has an influence on the development of the tumor. A capsule-like orientation will limit the escape of cancer cells from the tumor (1), whereas a perpendicular orientation will encourage escape and the invasion of nearby tissue (2). The orientation of the ECM and the fibroblasts can be quantified by image processing. (B) Experiments in which cancer cells are implanted into an animal have to be stopped when the primary tumor reaches a certain size to prevent unnecessary suffering (1). This can limit the data that can be collected on other aspects of cancer, such as metastasis. An alternative approach is to monitor each animal individually and to resection a tumor when it reaches a certain size (2): this allows for longer studies, including the collection of Kaplan-Meier survival curves similar to those collected during clinical trials.

Download links

A two-part list of links to download the article, or parts of the article, in various formats.

Downloads (link to download the article as PDF)

Download citations (links to download the citations from this article in formats compatible with various reference manager tools)

Open citations (links to open the citations from this article in various online reference manager services)