Reproducibility Project: Cancer Biology

Collection

1. 1. Cancer Biology
   2. Computational and Systems Biology

   Investigating the replicability of preclinical cancer biology

   Timothy M Errington et al.

   A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the original papers.
2. 1. Cancer Biology

   Reproducibility in Cancer Biology: Challenges for assessing replicability in preclinical cancer biology

   Timothy M Errington et al.

   A project to repeat experiments from high-impact papers in cancer biology encountered a series of challenges, many of which were caused by a lack of detail in the original papers.
3. 1. Cancer Biology

   Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

   Timothy M Errington et al.

   A project to repeat experiments from high-impact papers in cancer biology did not complete all replications, with challenges ranging from mundane reasons to unexpected methodological issues.
4. 1. Cancer Biology

   Reproducibility in Cancer Biology: What have we learned?

   Peter Rodgers, Andy Collings

   As the final outputs of the Reproducibility Project: Cancer Biology are published, it is clear that preclinical research in cancer biology is not as reproducible as it should be.
5. 1. Cancer Biology

   Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

   Hongyan Wang et al.

   Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
6. 1. Cancer Biology

   Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

   John Kerwin et al.

   Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
7. 1. Cancer Biology

   Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

   Mee Rie Sheen et al.

   Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
8. 1. Cancer Biology

   Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

   Anthony Essex et al.

   Editors' Summary: This Replication Study has reproduced important parts of the original paper.
9. 1. Cancer Biology

   Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

   Xuefei Yan et al.

   Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
10. 1. Cancer Biology

    Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

    Jeewon Kim et al.

    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
11. 1. Cancer Biology

    Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kathryn Eaton et al.

    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
12. 1. Cancer Biology

    Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

    John Repass, Reproducibility Project: Cancer Biology

    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
13. 1. Cancer Biology

    Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc

    L Michelle Lewis et al.

    Editors' Summary: This Replication Study has reproduced important parts of the original paper, but it also contains results that are not consistent with some parts of the original paper.
14. 1. Cancer Biology

    Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells

    John P Vanden Heuvel et al.

    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
15. 1. Cancer Biology

    Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    Megan Reed Showalter et al.

    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
16. 1. Cancer Biology

    Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Xiaochuan Shan et al.

    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
17. 1. Cancer Biology

    Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

    Fraser Aird et al.

    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
18. 1. Cancer Biology

    Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs

    Christine Mantis et al.

    Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
19. 1. Cancer Biology

    Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data

    Irawati Kandela et al.

    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
20. 1. Cancer Biology

    Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

    Stephen K Horrigan, Reproducibility Project: Cancer Biology

    Editors' Summary: The results in this Replication Study could not be interpreted.
21. 1. Cancer Biology

    Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations

    Stephen K Horrigan et al.

    Editors' Summary: The results in this Replication Study could not be interpreted.
22. 1. Cancer Biology

    Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

    Ajay Bhargava et al.
23. 1. Cancer Biology

    Registered report: Diverse somatic mutation patterns and pathway alterations in human cancers

    Vidhu Sharma et al.
24. 1. Cancer Biology

    Registered report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

    Vidhu Sharma et al.
25. 1. Cancer Biology

    Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation

    Adam D Richarson et al.
26. 1. Cancer Biology

    Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

    Ajay Bhargava et al.
27. 1. Cancer Biology

    Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

    Babette Haven et al.
28. 1. Cancer Biology

    Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

    Brad Evans et al.
29. 1. Cancer Biology

    Registered report: Interactions between cancer stem cells and their niche govern metastatic colonization

    Francesca Incardona et al.
30. 1. Cancer Biology

    Registered report: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

    Denise Chroscinski et al.
31. 1. Cancer Biology

    Registered report: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

    Samrrah Raouf et al.
32. 1. Cancer Biology

    Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors

    Edward Greenfield et al.
33. 1. Cancer Biology

    Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

    David Blum et al.
34. 1. Cancer Biology

    Science Forum: Is preclinical research in cancer biology reproducible enough?

    Patrick Bodilly Kane, Jonathan Kimmelman

    Results from the Reproducibility Project: Cancer Biology provide a picture of the rate of false positives in cancer preclinical research, but it is still not clear if research in this field is less reproducible than it should be.