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The Reproducibility Project: Cancer Biology is an initiative to independently replicate selected results from a number of high-profile papers in the field of cancer biology. For each paper a Registered Report detailing the proposed experimental designs and protocols for the replications is peer reviewed and published prior to data collection; the results of these experiments are then published as a Replication Study. The project is a collaboration between the Center for Open Science and Science Exchange.
The aim of the project is two-fold: to provide evidence about reproducibility in preclinical cancer research, and to identify the factors that influence reproducibility more generally. Interpreting the results reported in the Replication Studies requires a nuanced approach, as explained in this Editorial. To date four of the studies have reproduced important parts of the original papers; five of the studies have reproduced parts of the original papers but also contain results that could not be interpreted or are not consistent with some parts of the original paper; two of the studies could not be interpreted; and two studies did not reproduce the parts of the original papers that they attempted to reproduce.
Roger DavisReviewing Editor
Joaquin EspinosaReviewing Editor
Christopher GlassReviewing Editor
Michael R GreenReviewing Editor
Joan MassaguéReviewing Editor
Duojia PanReviewing Editor
Chi Van DangReviewing Editor