The Reproducibility Project: Cancer Biology is an initiative to independently replicate selected results from a number of high-profile papers in the field of cancer biology. For each paper a Registered Report detailing the proposed experimental designs and protocols for the replications is peer reviewed and published prior to data collection; the results of these experiments are then published as a Replication Study. The project is a collaboration between the Center for Open Science and Science Exchange.
The aim of the project is two-fold: to provide evidence about reproducibility in preclinical cancer research, and to identify the factors that influence reproducibility more generally. Interpreting the results reported in the Replication Studies requires a nuanced approach, as explained in this Editorial. To date five of the studies have reproduced important parts of the original papers; six of the studies have reproduced parts of the original papers but also contain results that could not be interpreted or are not consistent with some parts of the original paper; two of the studies could not be interpreted; and four studies did not reproduce the parts of the original papers that they attempted to reproduce.
Collection
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Cancer Biology
Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced important parts of the original paper.
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Cancer Biology
Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
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Cancer Biology
Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced important parts of the original paper, but it also contains results that are not consistent with some parts of the original paper.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced important parts of the original paper.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced important parts of the original paper.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced important parts of the original paper.
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Cancer Biology
Editors' Summary: This Replication Study did not reproduce those experiments in the original paper that it attempted to reproduce.
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Cancer Biology
Editors' Summary: This Replication Study has reproduced important parts of the original paper.
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Cancer Biology
Editors' Summary: The results in this Replication Study could not be interpreted.
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Cancer Biology
Editors' Summary: The results in this Replication Study could not be interpreted.
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