1. Epidemiology and Global Health
  2. Immunology and Inflammation
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Inflammation: Western diet shifts immune cell balance

  1. Christina M Bergey  Is a corresponding author
  1. Department of Genetics, Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, United States
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Cite this article as: eLife 2021;10:e72787 doi: 10.7554/eLife.72787
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The Western diet shifts monocytes to be pro-inflammatory in a macaque model

Macaques were fed either Western or Mediterranean-like diets, and the gene expression of their monocytes was profiled. The proportion of pro-inflammatory genes being activated was then computed (shown in graph). This revealed that genes overexpressed in the Mediterranean-like diet (represented by the olive branch) were less likely than chance (marked as zero) to be pro-inflammatory (data shown in green). Genes that were highly expressed in the monocytes of monkeys fed a Western-like diet (represented by the piece of meat) were more likely than expected by chance to be pro-inflammatory (data shown in red). The gene classification was based on prior direct comparisons of pro-inflammatory and regulatory monocytes (Schmidl et al., 2014).

Image credit: Data adapted from Johnson et al., 2021 (CC BY 4.0).

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