Browse our Research Advances

Page 44 of 51
    1. Neuroscience

    Simultaneous activation of parallel sensory pathways promotes a grooming sequence in Drosophila

    Stefanie Hampel, Claire E McKellar ... Andrew M Seeds
    A grooming sequence is produced by a neural architecture that readies different movements simultaneously, and a mechanism where prioritized suppression between the movements determines their sequential performance.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes

    Eric A Prinslow, Chad A Brautigam, Josep Rizo
    Isothermal titration calorimetry experiments clarify apparently discrepant results described previously and show that N-terminal sequences of complexin bind to SNARE complexes containing C-terminally truncated synaptobrevin when they include the syntaxin-1 juxtamembrane region.
    1. Neuroscience

    A common directional tuning mechanism of Drosophila motion-sensing neurons in the ON and in the OFF pathway

    Juergen Haag, Abhishek Mishra, Alexander Borst
    A common mechanism for computation of direction selectivity in the ON and OFF channel is demonstrated.
    1. Neuroscience

    Circular oligomerization is an intrinsic property of synaptotagmin

    Jing Wang, Feng Li ... James E Rothman
    Calcium-binding synaptotagmins are involved in ring oligomer formation, which allows synaptotagmins to synchronize neurotransmitter release to Ca2+ influx.
    1. Neuroscience

    Increasing suppression of saccade-related transients along the human visual hierarchy

    Tal Golan, Ido Davidesco ... Rafael Malach
    Similar to spontaneous eye blinks perceptual stability, despite small saccades, is related to actively silencing transients in the high-level ends of both ventral and dorsal visual cortices, while activity in low-level visual cortex remains unstable.
    1. Neuroscience

    Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation

    Zuzanna Brzosko, Sara Zannone ... Ole Paulsen
    Sequential neuromodulation by acetylcholine and dopamine enables correlational synaptic learning which, when incorporated into a computational model, yields effective navigation toward changing reward locations as in natural foraging behavior.
    1. Neuroscience

    Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila

    Zachary A Knecht, Ana F Silbering ... Paul A Garrity
    The neurons and receptors mediating moist air detection in Drosophila are identified, revealing that moist and dry air detection depend on overlapping Ionotropic Receptors and that these pathways are both critical for hygrosensation.
    1. Stem Cells and Regenerative Medicine

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu, Alanna Klose ... Joe V Chakkalakal
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.
    1. Cell Biology

    The Sec61 translocon limits IRE1α signaling during the unfolded protein response

    Arunkumar Sundaram, Rachel Plumb ... Malaiyalam Mariappan
    Building on previous work (Plumb et al., 2015), it is shown that the Sec61 translocon controls the oligomerization, activation and inactivation of Ire1α during endoplasmic reticulum stress.
    1. Biochemistry and Chemical Biology

    Control of lipid domain organization by a biomimetic contractile actomyosin cortex

    Sven Kenjiro Vogel, Ferdinand Greiss ... Petra Schwille
    Building on previous work (Vogel et al., 2013b), it is shown that myosin-driven actin filament rearrangements actively move, split or fuse individual lipid domains and change their overall shape.