Browse our Research Advances

Page 45 of 51
    1. Neuroscience

    Noradrenaline blockade specifically enhances metacognitive performance

    Tobias U Hauser, Micah Allen ... Raymond J Dolan
    The neurotransmitter noradrenaline selectively modulates metacognition, the conscious insight into one's performance, but does not alter perceptual decision making, revealing that different neuromodulators affect different stages of a decision making process.
    1. Medicine
    2. Microbiology and Infectious Disease

    Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

    Elin Näsström, Christopher M Parry ... Stephen Baker
    Mass spectrometry on plasma from patients with typhoid fever and other febrile disease identified and validated 24 metabolites that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui, Qinyu Zhu ... Junyu Xiao
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    1. Cell Biology

    Centriolar remodeling underlies basal body maturation during ciliogenesis in Caenorhabditis elegans

    Inna V Nechipurenko, Cristina Berciu ... Daniela Nicastro
    Building on previous work (Doroquez et al., 2014), it is shown that the centriole core of the basal body degenerates, but the outer wall remodels to template the ciliary axoneme in a subset of C. elegans ciliated sensory neurons.
    1. Neuroscience

    Stimulus background influences phase invariant coding by correlated neural activity

    Michael G Metzen, Maurice J Chacron
    Building on previous work (Metzen et al., 2016), a combination of neurophysiological and behavioral approaches reveals that changes in the background strongly impacts invariant coding and perception of behaviourally relevant signals.
    1. Neuroscience

    A cellular mechanism for inverse effectiveness in multisensory integration

    Torrey LS Truszkowski, Oscar A Carrillo ... Carlos D Aizenman
    Building on previous work (Felch et al., 2016), it is shown that inverse effectiveness, a central property of multisensory integration, in the optic tectum is mediated by the activation of NMDA-type glutamate receptors, resulting in a response greater than the sum of responses to each individual sensory modality.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP

    Kevin D Siegenthaler, Kristeen A Pareja ... Carolyn S Sevier
    Building on previous work (Wang et al., 2014), it is shown that the nucleotide exchange factor of the chaperone BiP (Sil1) unexpectedly facilitates the reduction of oxidized BiP.
    1. Structural Biology and Molecular Biophysics

    Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

    Ho Yee Joyce Fung, Szu-Chin Fu, Yuh Min Chook
    Building on previous work (Fung et al., 2015), the structures of eight new nuclear export signal (NES) peptides bound to Exportin CRM1 are reported, revealing striking diversity in NES structures, a small conserved secondary structural element, and a CRM1 residue that functions as a selectivity filter.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Single-molecule observation of DNA compaction by meiotic protein SYCP3

    Johanna L Syrjänen, Iddo Heller ... Luca Pellegrini
    Building on previous work (Syrjänen, Pellegrini, & Davies, 2014), it is shown that SYCP3 contributes to the architecture of meiotic chromosomes through local bridging interactions that result in large-scale compaction of the chromosome axis.
    1. Neuroscience

    The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness

    Olivia K Faull, Kyle TS Pattinson
    Building on previous work (Faull et al, 2016), it shown that the different connectivity profiles of the individual columns of the human periaqueductal gray support their proposed roles in human threat behaviours, such as freezing or fight/flight.