Browse our Research Articles

Page 195 of 1,400
    1. Neuroscience

    Cell type-specific connectome predicts distributed working memory activity in the mouse brain

    Xingyu Ding, Sean Froudist-Walsh ... Xiao-Jing Wang
    Large-scale modeling of the mouse brain revealed that working memory is modular and determined by long-range cell type-specific connections, thereby providing a framework to interpret brain-wide recordings during cognition.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations

    Ruth Charlotte Eccleston, Emilia Manko ... Nicholas Furnham
    A computational method for predicting evolutionary pathways to antimicrobial resistance, accounting for how epistatic interactions determine trajectories, is described.
    1. Cell Biology
    2. Developmental Biology

    Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

    Niklas Simon, Abu Safyan ... Shinya Matsuda
    The heparan sulfate chains of the glypican Dally stabilizes morphogen Dpp on the cell surface by antagonizing receptor-mediated Dpp internalization largely independent of direct interaction with Dpp.
    1. Genetics and Genomics

    Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo

    Swati Gaikwad, Fardin Ghobakhlou ... Alan G Hinnebusch
    Eliminating eukaryotic initiation factor 2 (eIF2) from wild-type budding yeast had little impact on translation of individual mRNAs, including those with regulatory upstream open-reading frames, even when canonical initiation factor eIF2 activity was impaired.
    1. Microbiology and Infectious Disease

    Physiological and metabolic insights into the first cultured anaerobic representative of deep-sea Planctomycetes bacteria

    Rikuan Zheng, Chong Wang ... Chaomin Sun
    A deep-sea Planctomycetes bacterium performs a unique budding mode of division and recruits chronic phages for metabolizing nitrogen through the function of auxiliary metabolic genes.
    1. Evolutionary Biology

    Measures of genetic diversification in somatic tissues at bulk and single-cell resolution

    Marius E Moeller, Nathaniel V Mon Père ... Weini Huang
    Single-cell and bulk sequencing data are combined through theoretical modeling to reveal the number of tissue-specific stem cells, mutation, and proliferation rates under sampling.
    1. Neuroscience

    The involvement of the human prefrontal cortex in the emergence of visual awareness

    Zepeng Fang, Yuanyuan Dang ... Mingsha Zhang
    While minimizing the report-related motor confounding, event-related potential (ERP), high-frequency power, and functional connectivity of the local field potential (LFP) activity in human prefrontal cortex were enhanced under the emergence of visual awareness.
    1. Neuroscience

    Passive exposure to task-relevant stimuli enhances categorization learning

    Christian Schmid, Muhammad Haziq ... Santiago Jaramillo
    Mice learn a categorization task faster when exposed to task-relevant stimuli outside training, supporting neural-network models in which unsupervised learning first captures the statistical structure of inputs before classifying them.
    1. Cell Biology

    Heparan sulfate promotes TRAIL-induced tumor cell apoptosis

    Yin Luo, Huanmeng Hao ... Ding Xu
    By binding to TRAIL and inducing its oligomerization, heparan sulfate plays a role in regulating the pro-apoptotic activity of TRAIL towards several types of tumor cells.
    1. Evolutionary Biology
    2. Medicine

    Taste shaped the use of botanical drugs

    Marco Leonti, Joanna Baker ... Julie Hawkins
    Plant drugs used by ancient Graeco-Roman societies have tastes and flavours that predict how they were used therapeutically.