Browse our Research Articles

Page 196 of 1,399
    1. Microbiology and Infectious Disease

    Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors

    Yuho Murata, Tsubasa Nishi ... Masao Yuda
    Sequential expression of two transcription factors that bind to five- and ten-base female-specific cis-acting elements, respectively, promotes differentiation of Plasmodium female gametocytes.
    1. Biochemistry and Chemical Biology

    Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

    Fabio Lolicato, Julia P Steringer ... Walter Nickel
    Disulfide-bridged fibroblast growth factor 2 (FGF2) dimerization at the inner plasma membrane leaflet produces the building block for higher FGF2 oligomers that drive FGF2 membrane translocation into the extracellular space.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Design principles for inflammasome inhibition by pyrin-only-proteins

    Shuai Wu, Archit Garg ... Jungsan Sohn
    Computational analyses and biochemical measurements redefine the mechanisms by which pyrin-only-proteins specifically target and regulate the assembly of inflammasomes.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Regulation of nuclear transcription by mitochondrial RNA in endothelial cells

    Kiran Sriram, Zhijie Qi ... Zhen Bouman Chen
    Mitochondrial RNAs attach to chromatin and regulate nuclear transcription in endothelial stress response.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions

    Jixing Lyu, Tianqi Zhang ... Arthur Laganowsky
    Native mass spectrometry reveals the thermodynamic basis for high-affinity lipid binding to the ABC transporter MsbA.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques

    Charlotte Rimbault, Christelle Breillat ... Matthieu Sainlos
    Engineering new intrabodies allows to develop selective and non-interfering tools for the visualization of endogenous PSD-95 with advanced imaging techniques.
    1. Neuroscience

    Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs

    Shuting Wu, Asem Wardak ... Wade G Regehr
    Purkinje cell inputs onto cerebellar nuclei (CbN) neurons have highly variable strengths, which allow them to influence CbN firing in a graded manner, with the largest individual inputs effectively regulating both the rate and spike timing of CbN neuron firing.
    1. Physics of Living Systems

    Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis

    Rajsekhar Das, Sumit Sinha ... D Thirumalai
    Theoretical explanation and a novel mechanism are given for the observation that viscosity of embryonic non-confluent tissue shows glass-like behavior till a critical cell density and saturates at higher densities.
    1. Computational and Systems Biology

    Analysis of NIH K99/R00 awards and the career progression of awardees

    Nicole C Woitowich, Sarah R Hengel ... Daniel J Tyrrell
    There is a significant disadvantage to receive a major grant (i.e., R01) for K99/R00 awardees that are women, those at lower funded institutions, and those with lower career mobility.
    1. Chromosomes and Gene Expression

    Regulation of chromatin architecture by transcription factor binding

    Stephanie Portillo-Ledesma, Suckwoo Chung ... Tamar Schlick
    The binding of transcription factors to mesoscale chromatin fibers leads to microdomains whose features are dependent on the linker DNA length, linker histone density, and tail acetylation levels.