Browse our Research Articles

Page 23 of 1,434
    1. Neuroscience

    Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration

    Katerina Rademacher, Zak Doric ... Ken Nakamura
    Following chronic hyperactivation using chemogenetics, vulnerable substantia nigra dopamine neurons display progressive degeneration unlike neighboring ventral tegmental area dopamine neurons.
    1. Ecology
    2. Evolutionary Biology

    Risk-taking incentives predict aggression heuristics in female gorillas

    Nikolaos Smit, Martha M Robbins
    Behavioural patterns among female gorillas indicate that animals guide their aggressive interactions towards more or less powerful groupmates depending on the conditions they experience.
    1. Developmental Biology

    The gut contractile organoid for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

    Rei Yagasaki, Ryo Nakamura ... Yoshiko Takahashi
    Functional organoids prepared from chicken embryonic gut consisting of pacemaker cells and smooth muscles undergo periodic contractions, offering a useful tool to understand rhythm control in multicellular systems.
    1. Microbiology and Infectious Disease

    Multi-omics single-cell analysis reveals key regulators of HIV-1 persistence and aberrant host immune responses in early infection

    Dayeon Lee, Sin Young Choi ... Jihwan Park
    KLF2 activity and impaired interferon signaling contribute to HIV-1 persistence by restricting antiviral immunity in infected CD4 T cells during early infection.
    1. Cell Biology

    A Commander-independent function of COMMD3 in endosomal trafficking

    Galen T Squiers, Chun Wan ... Jingshi Shen
    COMMD3 regulates endosomal trafficking outside the Commander holo-complex, revealing that a trafficking complex subunit can function independently of the entire complex.
    1. Cell Biology
    2. Developmental Biology

    The full-length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice

    Yan Huang, Nina Bucevic ... Ignasi Roig
    Disrupting full-length BEND2 impairs ovarian reserve establishment without causing male sterility, highlighting a sex-specific role in fertility and offering new insights into genetic contributions to infertility diagnosis and reproductive health.
    1. Biochemistry and Chemical Biology

    Action mechanism of a novel agrichemical quinofumelin against Fusarium graminearum

    Qian Xiu, Xiaoru Yin ... Yabing Duan
    The target of quinofumelin is DHODH in the de novo pyrimidine biosynthesis pathway.
    1. Neuroscience

    Inhibitory basal ganglia nuclei differentially innervate pedunculopontine nucleus subpopulations and evoke differential motor and valence behaviors

    Michel Fallah, Kenea C Udobi ... Rebekah C Evans
    The substantia nigra inhibits all PPN neurons and causes place aversion, while the globus pallidus selectively inhibits caudal non-cholinergic PPN neurons and causes place preference.
    1. Neuroscience

    Gliogenesis from the subventricular zone modulates the extracellular matrix at the glial scar after brain ischemia

    Maria Ardaya, Marie-Catherine Tiveron ... Fabio Cavaliere
    A population of ischemia-induced newborn astrocytes, positive for Thbs4, that migrate to the lesion border, where they produce and degrade hyaluronan, modulating the local extracellular matrix, has been identified.
    1. Neuroscience

    Identification of the trail-following pheromone receptor in termites

    Souleymane Diallo, Kateřina Kašparová ... Robert Hanus
    Identification of the trail-following pheromone receptor in the termite Prorhinotermes simplex represents the first functional characterization (deorphanization) of an odorant receptor in termites.