Endophilin A1 at postsynaptic sites promotes inhibitory postsynaptic organization through interaction with gephyrin to maintain E/I balance, which is essential for the suppression of epilepsy susceptibility.
Age-related differences in cortical aperiodic signals can be driven by cardiac influences, emphasizing the need to control for cardiac contributions in studies interpreting cortically measured aperiodic dynamics.
Yoshinori Kohwi, Xianrong Wong ... Terumi Kohwi-Shigematsu
Modified ChIP-seq and 4C-seq approaches, using urea-purified crosslinked chromatin, uncovered a two-tiered chromatin organization mediated by SATB1 that is linked to gene expression.
Shivraj M Yabaji, Vadim Zhernovkov ... Igor Kramnik
Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.
Across multiple scales, temporal context shapes visual perception through an attention-dependent process facilitating rapid motor responses and an attention-independent process suppressing neural encoding of expected events.
Patchy striatonigral neurons regulate implicit locomotor speed selection based on environmental valence, revealing a subtype-specific mechanism by which striatal circuits shape adaptive motor control and value-dependent behavioral responses.
Hey-Kyeong Jeong, Estibaliz Gonzalez-Fernandez ... Gareth M Thomas
Loss of ZDHHC9, a protein acyltransferase that is highly expressed in oligodendrocytes, does not grossly impact myelination but markedly alters oligodendrocyte morphology and myelination at the micro/nano-scale.
Electrophysiological recordings in female mice show that response profiles of accessory olfactory bulb neurons remain stable during the course of the estrus cycle.
