Small-molecule mitochondrial transcription factor A modulators stabilize mtDNA, preventing cytosolic escape and suppressing cGAS-STING interferon signaling, while improving bioenergetics and fibrosis markers in disease models.
Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.
Upregulated expression of transcription factors promoting cone identity in late-stage retinal progenitors drives development of the cone-dominant retina of 13-lined ground squirrels.
The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
Even in a simple epithelial tissue that is exposed uniformly to X-ray irradiation, cells show marked differences in their transcriptional response based on their location and cell-cycle status.
Marie Baldenius, Steffen Kautzmann ... Christian Klämbt
In Drosophila larva, the Uninflatable protein helps to switch from FGF-receptor triggered glial growth to Notch triggered wrapping of peripheral axons.
Inhibiting PRMT1 and PRMT5 renders HR-proficient ovarian and breast cancers highly vulnerable to PARP inhibition by suppressing BRCAness and amplifying DNA-damage-driven innate immune signaling.
Andria Koulle, Oluwaseun Ogundele ... Brian Hendrich
CHD4 directly limits transcription factor binding to chromatin, which prevents activation of silent or cryptic enhancers but facilitates activity of active enhancers.
