Anna Fijarczyk, Pauline Hessenauer ... Christian R Landry
A genomic analysis shows that the evolution of genome size and gene content among fungal pathogens in the class Sordariomycetes varies depending on their interactions with hosts and vectors.
Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.
The retrieval-extinction paradigm elicits a short-term fear amnesia that differs in cue specificity, timescale, and dependence on thought-control ability from the long-term amnesia believed to be associated with memory reconsolidation.
Analyzing population-level chromatin accessibility data shows added benefit over utilizing only gene expression data in elucidating the genetic mechanism of disease-associated variants.
Dario Cupolillo, Noelle Grosjean ... Christophe Mulle
A novel viral tool (FLEN) is designed, and used to monitor changes in the intrinsic and synaptic properties of engram cells quickly (3–6 hours) following encoding of a memory.
Daniel L Aldridge, Zachary Lanzar ... Christopher A Hunter
Functional analyses showcase that in the absence of IL-27, hematopoietic stem and progenitor cells are more likely to become monocytes during toxoplasmosis, making them less responsive after infection.
Alkis M Hadjiosif, Kahori Kita ... John W Krakauer
Patients with stroke often show impairment in both moving and holding the arm, deficits that are dissociable experimentally, suggesting that moving and holding are controlled by separate neural mechanisms.
An integrative analysis of scRNA-seq and spatial transcriptomics provides complementary views into the biology of pre-clinical colorectal cancer models in mice with possible applications to the human system.
