Bing Guo, Shannon Takala-Harrison, Timothy D O'Connor
hmmIBD outperforms alternative tools in detecting genome segments that are identical-by-descent and uncovering signals of positive selection and demographic history in malaria parasite genomes, underscoring the importance of tool prioritization and optimization for reliable malaria genomic surveillance.
Thomas Balligand, Claire Carpenet ... Maarten Dewilde
Two radio-labeled nanobodies and a single knock-in mouse model suffice to track the biodistribution of various unmodified cell-types in live mice by PET/CT.
The cryoEM structure of a RAD51 displacement loop reveals the molecular mechanism of the strand-exchange reaction at the centre of eukaryotic homologous recombination.
Wide-gauge posture in the limb skeleton of Titanosauriformes is an exaptation to gigantism, as it is not correlated with body size in deeply branching titanosaurs.
Rosanna P Sammons, Stefano Masserini ... Dietmar Schmitz
The asymmetric connectivity between thorny and athorny pyramidal neurons in the CA3 region is the key in maintaining the separation of peak firing during sharp wave events.
Population trajectories of premotor cortex mirror neurons progress through distinct subspaces during execution versus observation of reach-grasp-manipulate movements, yet latent dynamics can be aligned, indicating similar relationships among neural representations.
Janelle JY Chuah, Madalena R Daugherty, David M Smith
A single hydrophobic interaction drives allosteric gate-opening of the archaeal 20S proteasome, identifying a specific new target for therapeutic drug design.
YEATS2 and GCDH are upregulated in head and neck cancer in an SP1-dependent manner, leading to enhanced levels of promoter histone crotonylation which in turn elevates expression of EMT-associated SPARC.
Ruggiero Francavilla, Bidisha Chattopadhyaya ... Graziella Di Cristo
Syngap1 haploinsufficiency, which is associated with intellectual disability, epilepsy, and other cognitive and behavioral impairments, reduces the firing and excitatory drive of cortical interneurons.
Glycolysis and attenuates oxidative phosphorylation through long-chain fatty acids, while mitochondrial biogenesis and anabolism remain intact, to accelerate the progression of acute megakaryocytic leukemia.
