Browse our Research Articles

Page 24 of 1,442
    1. Biochemistry and Chemical Biology

    Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response

    CJ San Felipe, Jyoti Batra ... James S Fraser
    Lipid binding stabilizes the SARS-CoV-2 Orf9b homodimer, slowing its conversion to the Tom70-binding monomeric form and modulating interferon suppression.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary sex classification of somatic tissues

    Chen Xie, Sven Künzel, Diethard Tautz
    Sex-biased gene expression in the body organs evolves rapidly, supporting a mosaic model of maleness and femaleness across tissues and thus challenging binary views of sex characteristics in mammals.
    1. Neuroscience

    The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH signaling in dorsal and ventral forebrain

    María Pedraza, Valentina Grampa ... Justine Masson
    KIF7 loss of function affects several developmental stages of the cerebral cortex and likely causes neurodevelopmental delay, intellectual disability, and epilepsia observed in ciliopathic patients with KIF7 mutations.
    1. Cancer Biology
    2. Computational and Systems Biology

    Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

    Erika Tsingos, Advaita M Dick, Baubak Bajoghli
    Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Magnetotactic bacteria optimally navigate natural pore networks

    Alexander P Petroff, Julia Hernandez ... Nina Radchenko-Hannafin
    Diverse magnetotactic bacteria are adapted to the local geomagnetic field and grain size to maximize their swimming speed through the pore space.
    1. Neuroscience

    Structure transfer and consolidation in visual implicit learning

    Dominik Garber, József Fiser
    Sleep is essential for consolidating implicitly acquired perceptual knowledge that enables the knowledge transfer effect via newly learned structured information observed in prior studies of explicit learning.
    1. Microbiology and Infectious Disease

    Prophage regulation of Shewanella fidelis 3313 motility and biofilm formation with implications for gut colonization dynamics in Ciona robusta

    Ojas Natarajan, Susanne L Gibboney ... Larry J Dishaw
    Deleting SfPat prophage reduces Shewanella fidelis motility, increases biofilms, changes pdeB expression and spatial retention in Ciona gut, while Ciona VCBP-C binding to the WT strain results in reduced expression of viral capsid proteins without inducing SOS, indicating tripartite interactions.
    1. Evolutionary Biology

    The success of artificial selection for collective composition hinges on initial and target values

    Juhee Lee, Wenying Shou, Hye Jin Park
    Mathematical modeling uncovers how initial and target compositions limit microbial community selection, as inter-community selection clashes with intra-community selection like a rafter battling a waterfall.
    1. Cancer Biology

    SETD2 suppresses tumorigenesis in a KRASG12C-driven lung cancer model, and its catalytic activity is regulated by histone acetylation

    Ricardo J Mack, Natasha M Flores ... Or Gozani
    Genetic and biochemical studies show that SETD2 is tumor suppressive in a lung cancer mouse model and SETD2 methylation activity in vitro is regulated by histone acetylation.
    1. Cell Biology
    2. Evolutionary Biology

    Horizontally transferred cell-free chromatin particles function as autonomous ‘satellite genomes’ and vehicles for transposable elements within host cells

    Soumita Banerjee, Soniya Sanjay Shende ... Indraneel Mittra
    Uptake of cell-free chromatin particles released from dying cells and carrying non-coding DNA could redefine mammalian genomics.