Browse our Research Articles

Page 24 of 1,439
    1. Computational and Systems Biology
    2. Neuroscience

    Accept–reject decision-making revealed via a quantitative and ethological study of C. elegans foraging

    Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani
    C. elegans foraging decisions are guided by learned environmental features, integrating recent patch quality with internal satiety to balance exploration and exploitation.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity

    Khund Sayeed, Sreeja Parameswaran ... Matthew T Weirauch
    Infection of human cells by human cytomegalovirus induces massive changes to human chromatin and reduction of TEAD1 activity.
    1. Neuroscience

    Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of fragile X syndrome

    Huei-Bin Wang, Natalie E Smale ... Christopher S Colwell
    These findings provide convincing evidence of the beneficial effects that restored biological rhythms may have on disease pathophysiology and symptoms.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure-guided loop grafting improves expression and stability of influenza neuraminidase for vaccine development

    Pramila Rijal, Leiyan Wei ... Alain RM Townsend
    Grafting surface loops containing antibody epitopes of a poorly expressed flu neuraminidase protein onto a high-expressing, stable scaffold improves its production and stability for vaccine development.
    1. Neuroscience

    Prenatal light exposure affects number sense and the mental number line in young domestic chicks

    Rosa Rugani, Matteo Macchinizzi ... Lucia Regolin
    In ovo light exposure that induces brain lateralization boosts chicks' number sense and spatial-numerical association.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    The lipocone superfamily, a unifying theme in metabolism of lipids, peptidoglycan and exopolysaccharides, inter-organismal conflicts and immunity

    A Maxwell Burroughs, Gianlucca G Nicastro, L Aravind
    A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline

    Rui Feng, Sarah F Rosen ... Valeria Cavalli
    Inhibition of the endothelin B receptor (ETBR) with FDA-approved Bosentan enhances axon regeneration and reverses age-related decline, revealing a promising therapeutic target for improving nerve repair in older individuals.
    1. Immunology and Inflammation
    2. Neuroscience

    Glia-mediated gut–brain cytokine signaling couples sleep to intestinal inflammatory responses induced by oxidative stress

    Alina Malita, Anne H Skakkebaek ... Kim Rewitz
    Gut-to-brain communication via glial cytokine signaling links intestinal oxidative stress to altered sleep patterns, highlighting how gut inflammation can influence brain function and restorative sleep behaviors essential for mental well-being.
    1. Evolutionary Biology

    Genetic parallels in biomineralization of the calcareous sponge Sycon ciliatum and stony corals

    Oliver Voigt, Magdalena V Wilde ... Gert Wörheide
    Discovery of calcarins in calcareous sponges highlights gene duplication and neofunctionalization as drivers of parallel biomineralization, offering insight into the independent evolution of calcification in early-diverging animals.
    1. Neuroscience

    Preparatory attentional templates in prefrontal and sensory cortex encode target-associated information

    Zhiheng Zhou, Joy Geng
    fMRI decoding reveals that the inferior frontal junction-visual network reinstates target-related information as a proxy for target localization before visual search.