Rab10 and Rab4 bidirectionally regulate AMPA receptor trafficking and spine structural plasticity during long-term potentiation by exhibiting opposing and temporally distinct activity patterns in stimulated dendritic spines.
Christopher M Kim, Carson C Chow, Bruno B Averbeck
Neural activity during reversal learning encodes decision-related evidence integrated across trials and shows substantial dynamics during each trial, suggesting an extension of the line attractor model that incorporates non-stationary dynamics.
Roger Eloiflin, Elena Pérez-Antón ... Brice Rotureau
A novel array of CRISPR-based SHERLOCK tests for RNA detection was developed for eco-epidemiological surveillance of human and animal African trypanosomes from Western Africa with domestic pigs as sentinels.
Veronica H Ryan, Sydney Lawton ... Michael Emmerson Ward
Protein, but not mRNA, levels of neurodegenerative disease-associated protein TDP-43 are decreased upon knockdown of BORC, a complex that is required for the anterograde transport of lysosomes.
Elena G Govorunova, Oleg A Sineshchekov ... John L Spudich
Ancyromonad channelrhodopsins advance understanding of ionic selectivity and wavelength regulation in light-gated ion channels, and expand the toolkit for multiplexing with red-shifted fluorescent sensors.
Justin M Campbell, Rhiannon L Cowan ... Jon Timothy Willie
Firing rate analyses revealed neurons throughout the hippocampus, amygdala, orbitofrontal cortex, and anterior cingulate cortex in humans that exhibited heterogeneous responses to intracranial theta burst stimulation of the human brain.
A combination of cell biological, biochemical, and computational approaches characterizes the conserved membrane-targeting sequence of bactofilins and reveals a mutual influence of membrane binding and bactofilin polymerization.
