Exosome-associated THSD7A is identified as a key trigger of filopodia formation in cancer cells and neurons, revealing a novel pathway with implications for metastasis, neuronal connectivity, and other filopodia-dependent processes.
Synthetic ribbon-type active zones are reconstituted in cultured cells using a minimal set of proteins that partially mimic structural and functional features of cochlear inner hair cell active zones.
Magdalena Boch, Katrin Karadachka ... Rogier B Mars
A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future investigations of carnivoran neuroecology.
Estrogens produced in the teleost brain increase neural sensitivity to testicular androgens by directly stimulating androgen receptor transcription, thereby eliciting male-typical behaviors.
Multiomics and biochemical studies reveal that excess ATP levels, and not ROS, is the dominant driver for antibiotic cidality in Mycobacterium smegmatis.
Mathias Sablé-Meyer, Lucas Benjamin ... Stanislas Dehaene
fMRI and MEG results in adults and children show encoding of abstract geometric regularities in dorsal-parietal, temporal, and frontal regions, pointing to a system for symbolic geometric representation in humans.
Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
Linking biological research with disordered-systems modeling, providing new insights into gut microbiome stability, functioning, and their relationship with health.
J Ignacio Gutierrez, Claudia Edgar, Jessica K Tyler
Live imaging analyses in budding yeast reveal that calorie restriction and overexpression of the mRNA binding protein Ssd1 both block deleterious age-dependent iron uptake as a mechanism to extend lifespan.
