Carmen Ruger-Herreros, Lucia Svoboda ... Bernd Bukau
The nuclear J-domain protein Apj1 controls the shut-off phase of the yeast heat shock response by displacing DNA-bound heat shock transcription factor Hsf1.
Alexander N Kapustin, Sofia Serena Tsakali ... Catherine M Shanahan
Fibronectin triggers secretion of extracellular vesicles carrying collagen VI that regulate smooth muscle cell adhesion and migration during vascular repair and atherogenesis.
Neurons selective to running trajectories in the rat anterior cingulate cortex are reactivated during observation and interact with hippocampal replay to guide subsequent spatial navigation.
Ecem Altan, Catherine A Morgan ... D Samuel Schwarzkopf
Modulations in population receptive field size induced by spatial frequency adaptation reveal a direct link between spatial tuning in the visual cortex and spatial frequency selectivity of neuronal populations.
Rewiring the command neurons in the tactile circuit is sufficient to change the behavioral strategy of a whole animal, implying a 'plug-and-play' flexibility in sensorimotor circuits.
CryoCLEM-guided cryoET of Psd95-GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.
LINE-1-encoded ORF1p is widely expressed in neurons, increases with age, and engages neuron-specific protein partners, revealing a dynamic role for retrotransposons in brain physiology and aging.
Akinori Endo, Chikage Takahashi ... Yukiko Yoshida
Ubiquitin accumulated on damaged lysosomes activates TAB–TAK1–IKK–NF-κB axis and remodels proteome through gene expression for cell survival and cell-cell communication.
