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CTCF binding promotes chromatin-nuclear speckle interactions and gene activation after DNA demethylation, yet its binding and looping patterns are unaffected by speckle depletion.

WRN and WRNP1 ATPases together with WRN 3’ to 5’ exonuclease raise the fidelity of intrinsically highly error-prone Y-family DNA polymerases such that they perform error-free translesion synthesis.

Coarse-grained models of cellular growth and high-throughput empirical genetic data support the Product neutrality function in which a double-mutant fitness is the product of single-mutant fitnesses.

The cryptic pocket is critical for one of the VP35 protein's functions and therefore is likely under selective pressure.

Differences among genetically identical individuals can be explained using expression levels of just a handful of genes, suggesting that environmental variation can be functionally analyzed.

Peptide inhibitors of E3 ubiquitin ligase anaphase-promoting complex/cyclosome, engineered for enhanced affinity by incorporating unnatural amino acids, are able to block substrate ubiquitination and drive degradation of a fused target.

Environmental chloride ions act as essential counterions that enable coral opsins to respond to visible light, and the polar residue Glu292 plays a critical role in chloride binding.

Remains of the extinct hominin species Homo naledi were interred by members of their own species, the first time that burial has been documented in populations other than modern humans and Neanderthals.

Mesolimbic dopamine ramps emerge only when overall event rates are high, thereby providing a key constraint on theories of dopamine signaling.

A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.