Motor units within a pool exhibit distinct rate coding as force levels change, highlighting how gain control can transform inputs with limited bandwidth into the desired muscle force.
Computational modeling shows how neural mechanisms for mitigating biological constraints (such as neurons’ limited firing range) may eventually result in complex though predictable irrational behavior.
The perception of ambiguous steps in relative tone height is predicted by direction-selective cells in the auditory cortex, rather than the brain's represented distance between the tone heights.
Induction of regenerative cardiac cells (RCCs) from human embryonic stem cell-derived cardiomyocytes and neonatal rat cardiomyocytes using a novel two-compound treatment enhances heart function following myocardial infarction and offers a promising avenue for cardiac regeneration through transcriptional and epigenetic reprogramming.
Ignacy Czajewski, Bijayalaxmi Swain ... Daan MF van Aalten
Modelling O-GlcNAc transferase intellectual disability reveals the roles of this post-translational modification in regulating normal axonal terminal morphology and maintaining appropriate sleep homeostasis, pharmacological and genetic rescues of O-GlcNAcylation highlight the complexities of addressing this disorder.
In metastatic NSCLC patients, CHIP showed minimal impact on immunotherapy response but was more prevalent and associated with inflammatory pathways in myeloid cells, particularly in lung squamous cell carcinoma.
