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Knockout of the J domain protein DnaJC7 reduces tau aggregate clearance and increases intracellular tau seeding for recombinant and human brain-derived tau seed sources.

Comparing the inflammatory proteome of healthy Tanzanian and Dutch adults highlights a pro-inflammatory phenotype and metabolic differences in Tanzanians, with the potential role of food-derived metabolites in driving inflammation.

When looking at another person shifting their gaze, humans use the gazer's head direction, velocity, and peripheral visual information to infer potential gaze goals and execute anticipatory eye movements.

Rtf2 is shown to associate with multiple splicing factors and influence splicing of a subset of introns explaining why previous work erroneously assigned it as a replication restart factor in fission yeast.

Reductions in cervical cancer screening and colposcopy among nearly half of surveyed clinicians more than a year into the COVID-19 pandemic raise concerns that inadequate screening and follow-up will lead to future increases in preventable cancers.

Deciphering the dynamics of the allosteric communication and the formation of transient pockets along the activation pathway of G-protein-coupled receptors provides useful information for the design of allosteric modulators.

Female rats express higher levels of β noradrenergic receptor RNA in premotor cortex than males, and systemic blockade of these receptors diminished neural representation of action plans in premotor cortex and impaired decision-making performance, especially in females.

Polycystic ovary syndrome (PCOS) is a highly prevalent disorder of women, with significant reproductive, endocrine, and metabolic morbidities and a total healthcare-related economic burden exceeding $15 billion (2021 USD) for the U.S. alone, $4 billion due to mental health disorders.

The largest federally qualified health center in Massachusetts was able to improve cervical cancer screening rates during the COVID-19 pandemic by creating clinical sessions devoted only to screenings.

A gradient-based approach is employed to characterize the organization of functional connectivity in the human locus coeruleus, revealing age-related differences and associations with cognitive and affective functions independently from age.