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Ripple origination point shapes neural activity dynamics across the different hippocampal subfields.

Using fetal magnetic resonance imaging (MRI), maturational changes in tissue microstructure can be derived using diffusion MRI which provide new insight into the fundamental neurobiological transitions occurring within the emerging thalamocortical white matter pathways.

An Escherichia coli line lacking deoxyribonucleotide synthesis has been created and subjected to experimental evolution, revealing that endosymbionts and pathogens that lack ribonucleotide reduction avoid loss of deoxyribonucleotides to central metabolism by disruption of the salvage pathway.

High-throughput screening of over 6000 drugs using cells and retina tissue with a CEP290 ciliopathy mutation identified a small molecule, reserpine, which enhanced photoreceptor survival in retinal organoids and in a mouse disease model by partially restoring balance in proteostasis.

Neurons in the mouse superior colliculus comprise about 20 types based on their responses to visual stimuli, and neurons of the same type tend to cluster together.

Gut microbiota reshaped by myostatin gene variation has a positive effect on skeletal muscle growth by activating GPR43 through valeric acid, as a metabolite of gut microbiota.

Snake venom phosphodiesterase (svPDE), one of the critical venom components, is co-opted from the ancestral ENPP3 gene that makes membrane-anchored ENPP3 into secretory svPDE by using an alternative 5' exon.

Whole-brain computational modelling, incorporating novel ML-based parameter estimation techniques, reveals how transcranial magnetic stimulation-evoked brain responses are driven at earlier timepoints by local echoes of the external stimulus, and at later timepoints by large-scale network reverberation across the connectome.

TIR-1 regulates both repair and destruction on either side of an injury axon.

The levels of the cytokine BAFF increase across senescence paradigms, in turn triggering a secretory phenotype in some senescent cells and activating p53 in other senescent cells.