Browse our Research Articles

Page 262 of 1,373
    1. Neuroscience

    A task-general connectivity model reveals variation in convergence of cortical inputs to functional regions of the cerebellum

    Maedbh King, Ladan Shahshahani ... Jörn Diedrichsen
    Models of cortico-cerebellar connectivity are quantified using task-based fMRI, and demonstrate that convergent rather than sparse inputs best characterize cortico-cerebellar connectivity, namely, cerebellar areas linked to cognition receive the highest convergence of cortical inputs.
    1. Ecology
    2. Evolutionary Biology

    Complex plumages spur rapid color diversification in kingfishers (Aves: Alcedinidae)

    Chad M Eliason, Jenna M McCullough ... Michael J Andersen
    Treating color patterns in a geometric morphometrics framework reveals rapid rates of color evolution that are explained by a combination of intrinsic organismal features (color variation among patches) and geography within a cosmopolitan radiation of birds.
    1. Developmental Biology
    2. Neuroscience

    Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons

    Daniel T Pederick, Nicole A Perry-Hauser ... Liqun Luo
    Latrophilin-2 G protein coupling is required in axons but not target neurons for neural circuit assembly in the mouse hippocampus.
    1. Epidemiology and Global Health

    Disentangling the rhythms of human activity in the built environment for airborne transmission risk: An analysis of large-scale mobility data

    Zachary Susswein, Eva C Rest, Shweta Bansal
    Fine-grain mobility data empirically quantify the propensity for human mixing to be indoors across the US and improve understanding of the relationship between the physical environment and infection risk in light of global change.
    1. Physics of Living Systems

    Dynamics of immune memory and learning in bacterial communities

    Madeleine Bonsma-Fisher, Sidhartha Goyal
    Bacterial CRISPR immunity tracks phage mutations, creating immune diversity in bacterial populations that parallels phage genetic diversity and patterns of phage evolution that are determined by the type and degree of immune cross-reactivity in the CRISPR system.
    1. Genetics and Genomics

    Pooled genome-wide CRISPR activation screening for rapamycin resistance genes in Drosophila cells

    Baolong Xia, Raghuvir Viswanatha ... Norbert Perrimon
    A novel genome-wide transcriptional activation screening in Drosophila cells revealed the activation of InR-Akt-mTOR pathway by cholesterol in plasma membrane to confer resistance to Rapamycin.
    1. Cell Biology
    2. Neuroscience

    Regulation of different phases of AMPA receptor intracellular transport by 4.1N and SAP97

    Caroline Bonnet, Justine Charpentier ... Françoise Coussen
    Biochemistry, videomicroscopy, and immunocytochemistry reveal differential roles of GluA1/4.1N and GluA1/SAP97 interactions on GluA1 intracellular transport and exocytosis in basal transmission and during cLTP in cultured hippocampal neurons.
    1. Epidemiology and Global Health

    Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome

    Ricardo Cortez Cardoso Penha, Karl Smith-Byrne ... James D Mckay
    A novel Mendelian randomisation framework unravels one gene expression component, correlated with proliferation and genome stability-related features, associated with telomere length in lung adenocarcinoma tumours, which provides insights into how telomere length influences the genetic basis of lung cancer aetiology.
    1. Cancer Biology
    2. Computational and Systems Biology

    Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns

    Simon Grund Sørensen, Amruta Shrikhande ... Jakob Skou Pedersen
    Deficiencies of several DNA damage response genes can be predicted by their association with genome-wide mutation patterns.
    1. Medicine

    Tracing the path of 37,050 studies into practice across 18 specialties of the 2.4 million published between 2011 and 2020

    Moustafa Abdalla, Salwa Abdalla, Mohamed Abdalla
    Comprehensive decade-long analysis of point-of-care resources reveals insights into how clinical research makes its way into practice across different medical specialties and through time to enable us to identify potential translational bottlenecks in the pathway from research to practice.