Browse our Research Articles

Page 262 of 1,459
    1. Neuroscience

    Acute stress reduces effortful prosocial behaviour

    Paul AG Forbes, Gökhan Aydogan ... Claus Lamm
    Participants under acute stress were less willing to exert a relatively low level of physical effort for actions that benefit another person compared to actions that benefit themselves.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions

    Luka Jarc, Manuj Bandral ... Anthony Gavalas
    The signaling requirements to decouple proliferation of pancreatic progenitors from differentiation were elucidated and employed for the reproducible expansion, under GMP-compliant conditions, of pancreatic progenitors derived from different human pluripotent stem cell lines.
    1. Neuroscience

    Inhibitory CCK+ basket synapse defects in mouse models of dystroglycanopathy

    Jennifer N Jahncke, Daniel S Miller ... Kevin M Wright
    Loss of functional dystroglycan disrupts the formation and function of CCK+/CB1R+ inhibitory synapses in hippocampal CA1, resulting in reduced seizure thresholds in mouse models of dystroglycanopathy.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Selection on plastic adherence leads to hyper-multicellular strains and incidental virulence in the budding yeast

    Luke I Ekdahl, Juliana A Salcedo ... Helen A Murphy
    Yeast that were evolved to adhere to plastic surfaces for a few hundred generations became hyper-adherent and more virulent.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

    Nadja S Katheder, Kristen C Browder ... Heinrich Jasper
    Signaling through nicotinic acetylcholine receptors in enterocytes impacts barrier integrity in the Drosophila intestine by regulating formation of the peritrophic matrix.
    1. Neuroscience

    Modeling apical and basal tree contribution to orientation selectivity in a mouse primary visual cortex layer 2/3 pyramidal cell

    Konstantinos-Evangelos Petousakis, Jiyoung Park ... Panayiota Poirazi
    Apical and basal dendrites contribute differently to single-neuron orientation selectivity, highlighting the impact of feedforward and feedback signal interactions.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice

    Wenbin An, Maria Feola ... Yelena Ginzburg
    Dysregulated erythroblast-specific iron trafficking and regulation of iron metabolism provides evidence of a novel potential therapeutic target to reverse ineffective erythropoiesis in MDS.
    1. Ecology
    2. Genetics and Genomics

    Non-invasive real-time genomic monitoring of the critically endangered kākāpō

    Lara Urban, Allison K Miller ... Andrew Digby
    The application of real-time genomics by long-read nanopore sequencing to environmental samples creates a new trajectory for non-invasive genomics-based monitoring of critically endangered wildlife.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Efficient estimation for large-scale linkage disequilibrium patterns of the human genome

    Xin Huang, Tian-Neng Zhu ... Guo-Bo Chen
    Leveraging the X-LD method for estimating inter-chromosomal linkage disequilibrium in the human genome uncovers a universal extended LD pattern, consistent with observations in 1KG cohorts.
    1. Neuroscience

    Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells

    John A Gaynes, Samuel A Budoff ... Alon Poleg-Polsky
    A combination of glutamate imaging, multicompartmental modeling, and machine learning elucidates the peak theoretical and actual contributions of heterogeneous kinetics of presynaptic inputs to the computation of directional selectivity in retinal starburst amacrine cells.