Browse our Research Articles

Page 260 of 1,392
    1. Cell Biology

    Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

    Brett C Baggett, Kevin R Murphy ... Gideon Koren
    Ex vivo, in vitro, and computational modeling studies indicate a persistence of myofibroblast senescence in the infarct border zone with age which can disrupt conduction and promote arrhythmias via senescent myofibroblast-cardiomyocyte coupling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structural basis of the multi-step allosteric activation of Aurora B kinase

    Dario Segura-Peña, Oda Hovet ... Nikolina Sekulic
    An entropy switch controls the Aurora B autoactivation process through two distinct kinetic steps of phosphorylation.
    1. Genetics and Genomics
    2. Neuroscience

    Neural mechanisms of parasite-induced summiting behavior in ‘zombie’ Drosophila

    Carolyn Elya, Danylo Lavrentovich ... Benjamin de Bivort
    In zombie fruit flies, Entomophthora muscae-elicited summiting behavior is mediated by blood-borne factors and the host circadian-neurosecretory network.
    1. Neuroscience

    Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours

    Flavia Venetucci Gouveia, Jurgen Germann ... Clement Hamani
    Integrated imaging analysis of a large multi-center dataset showed that treatment of refractory aggressive behavior with hypothalamic deep brain stimulation is highly effective with specific clinical and neuroimaging features associated with treatment success.
    1. Neuroscience

    The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity

    Rebecca Jordan, Georg B Keller
    A brain-wide neuromodulatory system enables rapid cortical plasticity to occur by signaling sensorimotor prediction errors across wide regions of the cerebral cortex.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Neural circuit-wide analysis of changes to gene expression during deafening-induced birdsong destabilization

    Bradley M Colquitt, Kelly Li ... Michael S Brainard
    Large-scale gene expression analysis of the songbird brain identifies the molecular and cellular features of vocal motor circuits that are altered by the loss of hearing.
    1. Stem Cells and Regenerative Medicine

    Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

    Claudia Dominici, Oscar D Villarreal ... Stéphane Richard
    Inhibition of type I PRMTs increases the proliferation capabilities of MuSCs with altered cellular metabolism, while maintaining their stem-like properties such as self-renewal and engraftment potential.
    1. Microbiology and Infectious Disease

    The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila

    Dario Hüsler, Pia Stauffer ... Hubert Hilbi
    Intracellular growth of the bacterial pathogen Legionella pneumophila in the amoeba Dictyostelium discoideum implicates a bacterial fatty acid transporter as well as dynamic interactions of the distinct membrane-bound replication compartment with host cell lipid droplets.
    1. Neuroscience

    Neural dynamics underlying self-control in the primate subthalamic nucleus

    Benjamin Pasquereau, Robert S Turner
    Cost–benefit integration between the desirability of the expected reward and the imposed delay to delivery is supported by STN signals that dynamically combined both reward-related attributes to form a single integrated value estimate along an antero-posterior axis in this nucleus.
    1. Neuroscience

    Using light and X-ray scattering to untangle complex neuronal orientations and validate diffusion MRI

    Miriam Menzel, David Gräßel ... Marios Georgiadis
    Light and X-ray scattering on the same primate and human brain samples cross-validate each other and enable accurate mapping of axonal trajectories in regions with uni- and multi-directional nerve fibers, which can be used to validate diffusion MRI.