Browse our Research Articles

Page 350 of 1,393
    1. Computational and Systems Biology

    Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures

    Felix Proulx-Giraldeau, Jan M Skotheim, Paul François
    An evolutionary algorithm is used to build gene networks implementing cell size control, and suggests multiple ways for evolution to first build sizers and turn them into adders depending on evolutionary constraints.
    1. Structural Biology and Molecular Biophysics

    Inhibited KdpFABC transitions into an E1 off-cycle state

    Jakob M Silberberg, Charlott Stock ... Cristina Paulino
    The serine phosphorylated and inhibited KdpFABC complex (KdpFABS162-PC) adopts an off-cycle E1P tight state, due to an impaired E1P/E2P transition.
    1. Neuroscience

    Rapid reconstruction of neural circuits using tissue expansion and light sheet microscopy

    Joshua L Lillvis, Hideo Otsuna ... Barry J Dickson
    A new approach for fast, sparse neural circuit mapping allows circuit structure, physiology, and behavior to be quantified in the same animal and across many animals.
    1. Neuroscience

    The role of conjunctive representations in prioritizing and selecting planned actions

    Atsushi Kikumoto, Ulrich Mayr, David Badre
    Time-resolved decoding of EEG reveals the nature of representations of upcoming actions and how the planned action is selected from working memory.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL

    Donté Alexander Stevens, Christopher Beierschmitt ... Matthew D Daugherty
    Evolution-guided functional analyses identify an activating adaptor of the dynein intracellular transportation machinery, NINL, as a novel component of the antiviral immune response and reveal a mechanism by which viruses antagonize NINL function in a species-specific manner.
    1. Neuroscience

    Visual and motor signatures of locomotion dynamically shape a population code for feature detection in Drosophila

    Maxwell H Turner, Avery Krieger ... Thomas R Clandinin
    Neurons responsible for detecting local visual features are modulated by visual and motor-related forms of gain control that increase the threshold for detection when self-generated movement signals would dominate visual input.
    1. Neuroscience

    Internally generated time in the rodent hippocampus is logarithmically compressed

    Rui Cao, John H Bladon ... Marc W Howard
    Receptive fields for time in the hippocampus, like receptive fields for retinal space and receptive fields for numerosity, obey the Weber-Fechner law.
    1. Neuroscience

    Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error

    Jessica N Goedhoop, Bastijn JG van den Boom ... Ingo Willuhn
    The extracellular concentration of dopamine in the nucleus accumbens core is progressively diminished by white noise, an underutilized, easy-to-titrate aversive stimulus, but is unaffected by white-noise intensity, context valence, and associated probabilistic contingencies.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CD169+ macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

    Jamie Moore-Fried, Mahinder Paul ... Gregoire Lauvau
    CD169+ macrophages in the bone marrow of malaria-infected mice uptake infected red blood cells, and establish a functional interaction that is required to activate plasmacytoid dendritic cells to secrete type I interferon and leave the bone marrow.
    1. Computational and Systems Biology

    Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions

    Xiaoming Fu, Heta P Patel ... Ramon Grima
    A combined experimental and modeling approach provides insight into potential biases when inferring transcription rates from static mRNA distributions, and shows that correcting for cell-cycle phase and post-transcriptional noise provides rates that agree with live-cell transcription measurements.