Browse our Research Articles

Page 351 of 1,393
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

    Wenbo Liu, Xukun Lu ... Jianqiao Liu
    SRSF10 directly binds genes functioning in spermatogonia and regulates their alternative splicing, the defect of which can lead to progenitor expansion failure.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The landscape of transcriptional and translational changes over 22 years of bacterial adaptation

    John S Favate, Shun Liang ... Premal Shah
    Parallel changes in organismal evolution can be observed even with disparate genomic changes due to similarity in functional outcomes, such as changes in molecular phenotypes like gene expression patterns.
    1. Neuroscience

    Neural underpinning of a respiration-associated resting-state fMRI network

    Wenyu Tu, Nanyin Zhang
    Using simultaneous recordings of electrophysiology, respiration, and resting-state fMRI, a respiration-associated neural network is identified.
    1. Biochemistry and Chemical Biology

    Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control

    Meiling Wu, Anda Zhao ... Dongyun Shi
    Moderate exercise upregulated compensatory antioxidant capability and reached a high-level redox balance, whereas antioxidant intervention achieved a low-level redox balance by inhibiting oxidative stress for treating diabetes.
    1. Cancer Biology

    Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

    Hae J Park, Mark A Gregory ... James DeGregori
    Cellular and molecular analyses of human AML cells reveal a novel pathway activated by the bone marrow microenvironment that confers resistance to FLT3 inhibition and can be exploited to improve the efficacy of FLT3 inhibitor therapy for AML.
    1. Microbiology and Infectious Disease

    Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis

    Hina Khan, Partha Paul ... Dibyendu Sarkar
    The two global regulators CRP and PhoP interact with each other to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis.
    1. Neuroscience

    Neural dynamics of causal inference in the macaque frontoparietal circuit

    Guangyao Qi, Wen Fang ... Liping Wang
    In causal inference, the premotor cortex dynamically integrates prior information and current sensory inputs to infer hidden structures, and selectively updates sensory representations in the parietal cortex to support behavior.
    1. Neuroscience

    Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice

    Amol Bhandare, Joseph van de Wiel ... Nicholas Dale
    Recordings from brainstem nuclei involved in chemosensory regulation of breathing in awake freely behaving mice show different complementary types of neuronal responses to hypercapnia in the retrotrapezoid nucleus and the rostral medullary raphe.
    1. Neuroscience

    Precise and stable edge orientation signaling by human first-order tactile neurons

    Vaishnavi Sukumar, Roland S Johansson, J Andrew Pruszynski
    Individual human first-order tactile neurons, those that innervate the mechanoreceptors in the skin, can signal information about edge orientation differences at the limit of what people can feel and across a broad range of speeds relevant for real-world hand use.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway

    Robert Krause, Jumari Snyman ... Alasdair Leslie
    A skewed B cell response in people living with HIV proceeds via an extrafollicular path and could result in reduced affinity B cell memory and antibody responses.