Browse our Research Articles

Page 42 of 1,434
    1. Immunology and Inflammation

    Hypothermia protects against ventilator-induced lung injury by limiting IL-1β release and NETs formation

    Nobuyuki Nosaka, Vanessa Borges ... Kenichi Shimada
    Therapeutic hypothermia mitigates ventilator-induced lung injury by suppressing macrophage-derived IL-1β release, thereby reducing neutrophil extracellular trap formation, vascular leakage, and hypoxemia in a two-hit acute lung injury model.
    1. Neuroscience

    A direct neural signature of serial dependence in working memory

    Cora Fischer, Jochen Kaiser, Christoph Bledowski
    Magnetoencephalographic recordings revealed a direct neural signature of serial dependence, that is, an attractive bias of current toward previous representations, which emerged at late, post-encoding stages of processing in working memory.
    1. Neuroscience

    Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

    Zhengming Tian, Yuning Li ... Jia Liu
    Exosomal mRNA transfer from non-neuronal cells to neurons under hypoxia drives hemoglobin expression and preserves mitochondrial homeostasis as an intercellular protective mechanism.
    1. Neuroscience
    2. Physics of Living Systems

    The geometry and dimensionality of brain-wide activity

    Zezhen Wang, Weihao Mai ... Quan Wen
    Neural activity patterns in randomly sampled neuron groups statistically match whole-brain dynamics, revealing a scale-invariant organizational principle that enables robust and efficient computation across brain regions and species.
    1. Neuroscience

    Cognitive control of behavior and hippocampal information processing without medial prefrontal cortex

    Eun Hye Park, Kally C O'Reilly Sparks ... André A Fenton
    Rodent medial prefrontal cortex is not crucial for an active place avoidance task requiring cognitive control evidenced by hippocampal activity that purposefully alternates between task-relevant and task-irrelevant representations of the environment.
    1. Neuroscience

    Synaptic connectivity of sensorimotor circuits for vocal imitation in the songbird

    Massimo Trusel, Ziran Zhao ... Todd F Roberts
    Optogenetic circuit mapping identifies the synaptic connectivity of input/output pathways in the songbird premotor region HVC, providing a basis for understanding information flow through brain circuits for song.
    1. Microbiology and Infectious Disease

    Regulative synthesis of capsular polysaccharides in the pathogenesis of Streptococcus suis

    Xingye Wang, Jie Wang ... Beinan Wang
    Streptococcus suis enhances its pathogenicity by dynamically expressing capsular polysaccharides.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    Roman O Fedoryshchak, Karim El-Bouri ... Richard Treisman
    Proteomics with PP1-Neurabin fusion proteins identify the 4E-BP proteins as novel Neurabin/PP1 substrates, and interaction with the Neurabin PDZ domain shown to be the major determinant of Neurabin/PP1 substrate specificity.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR

    Yan Zhang, Jingwan Han ... Zhihu Zhao
    HiCapR uncovers HIV RNA homodimers and long-range interactions that show structural dynamics critical for viral packaging and assembly.
    1. Computational and Systems Biology
    2. Neuroscience

    Evidence from pupillometry, fMRI, and RNN modelling shows that gain neuromodulation mediates task-relevant perceptual switches

    Gabriel Wainstein, Christopher J Whyte ... James M Shine
    Phasic neuromodulatory bursts actively drive adaptive perceptual updating by triggering large-scale brain network reconfigurations, as demonstrated through integrated pupillometry, fMRI, and computational modelling.