Browse our Research Articles

Page 627 of 1,423
    1. Cell Biology

    A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin-induced corpus luteum regression

    Dianrong Li, Jie Chen ... Xiaodong Wang
    A phosphorylation of receptor interacting RIPK3 switches its pro-necroptosis function to apoptosis that promotes luteal regression which induced by Prostaglandin F2alpha.
    1. Neuroscience

    Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice

    Ayla Aksoy-Aksel, Andrea Gall ... Ingrid Ehrlich
    Dopaminergic input shapes activity of specialized amygdala inhibitory cell clusters by ionotropic and metabotropic mechanisms that may enable their selection during distinct fear-related behavioral states.
    1. Developmental Biology
    2. Neuroscience

    A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS

    Brandon Mark, Sen-Lin Lai ... Chris Q Doe
    Neurons are mapped for developmental features (lineage, hemilineage, temporal identity) and connectomic features (morphology, synapse localization and connectivity) to reveal correlations that can be tested experimentally.
    1. Developmental Biology
    2. Neuroscience

    Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

    Xin Zhou, Seula Shin ... Jian Hu
    Qki-Srebp2–mediated cholesterol biosynthesis is indispensable for myelinogenesis during early brain development.
    1. Immunology and Inflammation

    NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase

    Khursheed A Wani, Debanjan Goswamy ... Javier E Irazoqui
    Genetic and molecular characterization showed that evolutionarily conserved flavin-containing monooxygenase (FMO-2) plays an important role in host defense in Caenorhabditis elegans, and its induction is dependent on conserved transcription factors, TFEB and PPAR-α.
    1. Physics of Living Systems

    Mesoscale phase separation of chromatin in the nucleus

    Gaurav Bajpai, Daria Amiad Pavlov ... Samuel Safran
    Computer simulations show transitions between novel types of chromatin organization (peripheral, central, conventional) depending on chromatin interactions with itself, the lamin and nuclear hydration, measured in recent experiments.
    1. Neuroscience

    Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity

    Juliette Boeri, Claude Meunier ... Antonny Czarnecki
    A simple mechanism, based on the synergy of two major opposing voltage-dependent currents that are ubiquitous in neurons, produces functional diversity of developing Renshaw cells in the embryo.
    1. Neuroscience

    Corollary discharge promotes a sustained motor state in a neural circuit for navigation

    Ni Ji, Vivek Venkatachalam ... Aravinthan DT Samuel
    A primary sensory interneuron in the thermotaxis circuit of C. elegans integrates sensory input and corollary discharge to drive persistent navigational states and movement towards preferred environments.
    1. Immunology and Inflammation

    CD8+ T cell self-tolerance permits responsiveness but limits tissue damage

    Emily N Truckenbrod, Kristina S Burrack ... Stephen C Jameson
    Identification and characterization of the responses of T lymphocytes that are specific for 'self' tissue antigens, revealing the functional limits of immune tolerance.
    1. Developmental Biology
    2. Physics of Living Systems

    Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos

    Yusuke Mii, Kenichi Nakazato ... Shinji Takada
    Wnt distribution is regulated by a dynamic exchange of its abundant scaffold-bound and rare freely diffusing populations, providing insights into a conceived dilemma of speed and stability of tissue patterning.