Browse our Research Articles

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    1. Cell Biology

    Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

    Sara Sannino, Megan E Yates ... Jeffrey L Brodsky
    Unique integrate stress response sensors differentially trigger pro-survival versus pro-apoptotic responses in cells confronted with Hsp70 inhibitor-associated proteotoxic challenges.
    1. Neuroscience

    Stability of neocortical synapses across sleep and wake states during the critical period in rats

    Brian A Cary, Gina G Turrigiano
    Sleep and wake states are not sufficient to drive changes in neocortical synaptic strengths.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle

    Cameron Hill, Elisabetta Brunello ... Malcolm Irving
    The physiological contraction of skeletal muscle is controlled by structural changes in the thick filaments, establishing a new paradigm for developing potential treatments for muscle weakness.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

    Lucie Zilova, Venera Weinhardt ... Joachim Wittbrodt
    Fish-derived pluripotent cells instinctively form retinal tissue recapitulating key steps of early eye development.
    1. Neuroscience

    Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

    Yongzhi Huang, Bomin Sun ... Huiling Tan
    Increased theta/alpha band activities within the habenula area and the prefrontal cortex, as well as the increased synchrony between the two structures in the same frequency band can serve as an indicator for negative emotions in humans.
    1. Cell Biology
    2. Physics of Living Systems

    Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells

    Saurabh Kulkarni, Jonathan Marquez ... Mustafa K Khokha
    Embryonic and mechanical manipulations of Xenopus multiciliated epithelium reveals that cell non-autonomous tensile forces generated by embryonic elongation calibrate cilia number in multiciliated cells via a mechanosensitive ion channel, Piezo1.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Injection with Toxoplasma gondii protein affects neuron health and survival

    Oscar A Mendez, Emiliano Flores Machado ... Anita A Koshy
    Multi-level profiling of Toxoplasma gondii-injected neurons identifies brain regions and neuron subtype predilections as well as the effect of Toxoplasma interactions on neuron physiology and health.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Identical sequences found in distant genomes reveal frequent horizontal transfer across the bacterial domain

    Michael Sheinman, Ksenia Arkhipova ... Florian Massip
    Horizontal gene transfer between distantly related bacterial species is frequent and widespread and can be efficiently identified using alignment-free methods.
    1. Neuroscience

    De novo learning versus adaptation of continuous control in a manual tracking task

    Christopher S Yang, Noah J Cowan, Adrian M Haith
    Humans can rapidly build a new controller when learning continuous movement tasks and can flexibly integrate this process with adaptation of an existing controller.
    1. Neuroscience

    A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories

    Ana C Sias, Ashleigh K Morse ... Kate M Wassum
    The bidirectional orbitofrontal cortex-basolateral amygdala circuit helps us to learn the details of predicted rewarding events and then to use that information to make good reward pursuit decisions.