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PGE2/EP4 skeleton interoception regulates bone and fat metabolism via hypothalamic NPY.

Neurons in the brain exhibit activity with various relations to locomotion and these signals are best decoded by combining activities from many neurons.

Network symmetry represents a new vantage point for dissecting complex information processing characteristics in multisite modification, and the breaking of symmetry can confer ordering of modification and absolute concentration robustness.

Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.

A neural network model with asymmetric synaptic interactions can store and retrieve multiple continuous memory sequences with their temporal structure.

A decrease of the type 2 myotonic dystrophy gene product CNBP causes an impairment of polyamine metabolism and locomotor dysfunction that can be reverted with polyamine supplementation.

The inhibitory protein DEPTOR make two widely separated interactions with mTOR that are both necessary for its unique partial mTOR inhibition, and DEPTOR is a more potent inhibitor of mutation- or RHEB-activated mTORC1 than basal mTORC1.

Structural and functional analysis reveals the mechanistic basis for mammalian target of rapamycin (mTOR)-dependent roles of DEP domain-containing mTOR interacting protein (DEPTOR) in cancer and metabolic regulation.

A comprehensive functional analysis of mitochondrial Ca²⁺ uniporter (MCU) demonstrates that the auxiliary MICU subunits potentiate Ca²⁺ transport via MCU.

Cytoplasmic bodies sequester important abscission machinery to delay completion of cytokinesis in response to mitotic errors.