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Topoisomerase 2α DNA breaks induced by G-quadruplex ligands are associated with a topological stress resulting from a transcription-dependent mechanism and counteracted by DNA topoisomerase 1 and factors promoting transcription elongation.

Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.

First evidence of cohesin folding occurring in vivo and during cohesion together with a detailed description of the structural aspects of cohesin's elbow folding through a series of novel structures.

Tsc1 mutation in cerebellar Purkinje cells leads to downregulation of synapse genes that are targets of the Fragile X Mental Retardation Protein.

A novel pair-of-pairs matching approach finds that community-level reductions in malaria burden can potentially substantially reduce the low birth weight rate in sub-Saharan Africa, particularly among firstborns.

Viruses, including SARS-CoV-2, retain infectivity longer at low temperatures and extreme relative humidities because these conditions slow down the chemical reactions that inactivate those viruses.

Excitatory output neurons in dorsomedial prefrontal cortex display heterogeneously specialized coding properties that evolve during cue-reward learning and predict cue-driven reward seeking.

A distinct neural network, including the nucleus accumbens as a central hub, is active when rats are exposed to trapped ingroup members they had previously helped escape a trap, but not for outgroup members who had not been helped.

Vaccination activities that occurred before the COVID-19 pandemic, 2000-2019, are estimated to avert 50 million deaths, highlighting the enormous benefits of continued and improving vaccination.

Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.