Browse our Research Articles

Page 628 of 1,392
    1. Cell Biology
    2. Developmental Biology

    TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

    Xiaochen Fan, V Pragathi Masamsetti ... Patrick PL Tam
    Network propagation connects TWIST1 with epigenetic regulators CHD7, CHD8, and WHSC1, which collectively promote the bias toward neural crest while suppressing neural stem cell programmes, and subsequently enhance ectomesenchyme potential.
    1. Cell Biology

    In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates

    Weirui Ma, Gang Zhen ... Christine Mayr
    Binding of a multivalent RNA-binding protein to mRNAs that are able to form pervasive RNA–RNA interactions induces formation of mesh-like condensates, whereas binding of mostly structured mRNAs induces sphere-like condensates.
    1. Cell Biology
    2. Developmental Biology

    Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

    Eric T Hall, Miriam E Dillard ... Stacey K Ogden
    Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.
    1. Genetics and Genomics

    A confinable home-and-rescue gene drive for population modification

    Nikolay P Kandul, Junru Liu ... Omar S Akbari
    Generation of a home-and-rescue gene drive targeting an essential gene reveals confinable population modification.
    1. Microbiology and Infectious Disease

    A conserved cell division protein directly regulates FtsZ dynamics in filamentous and unicellular actinobacteria

    Félix Ramos-León, Matthew J Bush ... Susan Schlimpert
    Identification of a novel regulator that directly influences the assembly and function of the cell division machinery in industrially and medically important bacteria.
    1. Neuroscience

    Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

    Trisha V Vaidyanathan, Max Collard ... Kira E Poskanzer
    Cortical astrocytes play key roles in NREM sleep by regulating sleep depth and duration through separate GPCR pathways, and differentially control neuronal slow-wave activity in local and remote cortical circuits.
    1. Cell Biology

    Bardet–Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome

    Yan-Xia Liu, Bin Xue ... Zhen-Chuan Fan
    Bardet–Biedl syndrome 3 (BBS3) protein promotes phospholipase D to load onto the BBSome at the ciliary tip for moving out of the cilium via intraflagellar transport.
    1. Neuroscience

    Functional reallocation of sensory processing resources caused by long-term neural adaptation to altered optics

    Antoine Barbot, Woon Ju Park ... Geunyoung Yoon
    Chronic exposure to poor optical quality causes a functional reallocation of sensory processing resources that favors perceptual information less affected by the eye's optics.
    1. Epidemiology and Global Health
    2. Medicine

    Quantifying the impact of quarantine duration on COVID-19 transmission

    Peter Ashcroft, Sonja Lehtinen ... Sebastian Bonhoeffer
    Test-and-release quarantine strategies for traced contacts of confirmed SARS-CoV-2 cases and returning travellers can reduce average quarantine durations while remaining as effective as 10 days of quarantine without testing.
    1. Microbiology and Infectious Disease

    MetaHiC phage-bacteria infection network reveals active cycling phages of the healthy human gut

    Martial Marbouty, Agnès Thierry ... Romain Koszul
    Physical contacts of bacteria and phage genomes allow in situ exploration of underdocumented phage families in the gut.