Elizabeth M Steenkiste, Jason D Berndt ... Jonathan A Cooper
Epithelial cells coordinate integrin signaling with protrusion via a two-protein module, with one protein defining localization and downstream signaling, the other serving as a phosphorylation switch and providing negative feedback.
Rebecca Feyh, Nadine B Waeber ... Florian Altegoer
The novel cryo-electron microscopy structure of a bacterial protein-only RNase P illustrates how a small protein oligomerizes into a dodecameric assembly to catalyze the 5’-end maturation of tRNAs.
Yeast bromodomain-containing factors Bdf1/2 offer insights into the biological role of the BET family of transcriptional regulators, which is a promising target in cancer therapy.
Markus Pfenninger, Friederike Reuss ... Barbara Feldmeyer
European beech harbours substantial genetic variation at genomic loci associated with drought resistance and newly identified loci can help to accelerate and monitor adaptation to climate change.
Haritha Mathsyaraja, Jonathen Catchpole ... Robert N Eisenman
The MYC transcription factor network member MGA is a subunit of a non-canonical Polycomb complex, which, when inactivated, accelerates tumorigenesis in mouse models of cancer and proliferation in colon organoids.
Timothy M Wolock, Seth Flaxman ... Jeffrey W Eaton
Integrating the sinh-arcsinh distribution into a distributional regression framework allows us to produce precise, local estimates of sexual age-mixing, facilitating more accurate modelling of sexually transmitted disease dynamics.
Routine and campaign vaccination disruption in 2020 may lead to measles outbreaks and yellow fever burden increases in some countries, but is unlikely to greatly increase meningococcal A burden.
