Computational modeling shows how neural mechanisms for mitigating biological constraints (such as neurons’ limited firing range) may eventually result in complex though predictable irrational behavior.
Motor units within a pool exhibit distinct rate coding as force levels change, highlighting how gain control can transform inputs with limited bandwidth into the desired muscle force.
Ignacy Czajewski, Bijayalaxmi Swain ... Daan MF van Aalten
Modelling O-GlcNAc transferase intellectual disability reveals the roles of this post-translational modification in regulating normal axonal terminal morphology and maintaining appropriate sleep homeostasis, pharmacological and genetic rescues of O-GlcNAcylation highlight the complexities of addressing this disorder.
Maternal obesity mouse model reveal that melatonin deficiency causes the genomic hyper-methylation of oocytes via increasing the expression of DNA methyltransferases.
In metastatic NSCLC patients, CHIP showed minimal impact on immunotherapy response but was more prevalent and associated with inflammatory pathways in myeloid cells, particularly in lung squamous cell carcinoma.
Poor intracellular availability and diffusion of weakly basic, small molecule drugs can be greatly enhanced by preventing ion trapping in crowded cellular environments.
Bikash Adhikari, Katharina Schneider ... Elmar Wolf
A rapamycin-induced proximity assay enables rapid identification of optimal E3 ligases for target protein degradation in living cells, streamlining early-stage proteolysis targeting chimera development.
Cryo-electron tomography uncovers the flexible, filamentous architecture of mouse ciliary rootlets and their regular cross-striations with extensive membrane connections.
