Browse our Research Articles

Page 682 of 1,406
    1. Neuroscience

    Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex

    Sarah Ruediger, Massimo Scanziani
    Neural pathways from mammalian visual cortex to ancestral brain structures control learning speed and performance of a simple detection task.
    1. Neuroscience

    Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

    Jeong Hyang Park, Chang Geon Chung ... Sung Bae Lee
    Genetic and optogenetic analyses in Drosophila neurons reveal calcium as one of the key regulators of nucleocytoplasmic localization of TDP-43 via Calpain-A and Importin α3.
    1. Neuroscience

    A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila

    Tsai-Ning Li, Yu-Jung Chen ... Chi-Kuang Yao
    The interplay between the Flower Ca2+ channel and PI(4,5)P2 spatiotemporally couples synaptic vesicle exocytosis to activity-dependent bulk endocytosis and synaptic vesicle reformation from bulk endosomes.
    1. Genetics and Genomics

    PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock

    Christina M Kelliher, Randy Lambreghts ... Jay C Dunlap
    Casein kinase I, a pivotal kinase in the circadian clock encoded by ck-1a, is positively regulated by a novel RNA-binding protein that protects ck-1a transcripts from nonsense-mediated decay.
    1. Neuroscience

    Tracking prototype and exemplar representations in the brain across learning

    Caitlin R Bowman, Takako Iwashita, Dagmar Zeithamova
    Concepts can be represented at multiple levels of specificity (individual examples, abstract category averages) within a single task across different regions of the brain.
    1. Computational and Systems Biology

    A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates

    Dennis Wang, James Hensman ... Frank Dondelinger
    Quantification of uncertainty in drug dose-responses provides a more robust metric for differentiating drugs and identifying biomarkers of response.
    1. Medicine

    The role of extracellular matrix phosphorylation on energy dissipation in bone

    Stacyann Bailey, Grazyna E Sroga ... Deepak Vashishth
    Global extracellular bone matrix phosphorylation level is optimized for appropriate mechanical function and is affected by the presence and heterogeneity in phosphorylation of osteopontin.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Cohesin mutations are synthetic lethal with stimulation of WNT signaling

    Chue Vin Chin, Jisha Antony ... Julia A Horsfield
    Hypersensitivity of cohesin-deficient cells to Wnt signaling is concomitant with beta catenin stabilization and offers promise that Wnt agonists could be therapeutically effective in cohesin mutant cancers.
    1. Cell Biology
    2. Developmental Biology

    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

    Clemens Heissenberger, Jarod A Rollins ... Markus Schosserer
    In nematode worms, NSUN-1 methylates ribosomal RNA and influences phenotypes related to aging, stress resistance, germ line development, and cuticle integrity by regulating translation of specific mRNAs.
    1. Structural Biology and Molecular Biophysics

    The mechanism of kinesin inhibition by kinesin-binding protein

    Joseph Atherton, Jessica JA Hummel ... Carolyn A Moores
    Cryo-electron microscopy reveals how kinesin-binding protein inhibits microtubule attachment in a subset of kinesins.