Jeong Hyang Park, Chang Geon Chung ... Sung Bae Lee
Genetic and optogenetic analyses in Drosophila neurons reveal calcium as one of the key regulators of nucleocytoplasmic localization of TDP-43 via Calpain-A and Importin α3.
The interplay between the Flower Ca2+ channel and PI(4,5)P2 spatiotemporally couples synaptic vesicle exocytosis to activity-dependent bulk endocytosis and synaptic vesicle reformation from bulk endosomes.
Christina M Kelliher, Randy Lambreghts ... Jay C Dunlap
Casein kinase I, a pivotal kinase in the circadian clock encoded by ck-1a, is positively regulated by a novel RNA-binding protein that protects ck-1a transcripts from nonsense-mediated decay.
Caitlin R Bowman, Takako Iwashita, Dagmar Zeithamova
Concepts can be represented at multiple levels of specificity (individual examples, abstract category averages) within a single task across different regions of the brain.
Stacyann Bailey, Grazyna E Sroga ... Deepak Vashishth
Global extracellular bone matrix phosphorylation level is optimized for appropriate mechanical function and is affected by the presence and heterogeneity in phosphorylation of osteopontin.
Hypersensitivity of cohesin-deficient cells to Wnt signaling is concomitant with beta catenin stabilization and offers promise that Wnt agonists could be therapeutically effective in cohesin mutant cancers.
Clemens Heissenberger, Jarod A Rollins ... Markus Schosserer
In nematode worms, NSUN-1 methylates ribosomal RNA and influences phenotypes related to aging, stress resistance, germ line development, and cuticle integrity by regulating translation of specific mRNAs.