Direct and indirect pathways in the basal ganglia have opposing effects not only on action performance but also on internal timing of expected reward delivery.
Janine D Brunner, Roman P Jakob ... Stephan Schenck
Structural and functional analysis of a recently discovered non-canonical potassium channel family reveals a unique selectivity filter that is exposed to permeating ions only in the conductive state.
Anna Plana-Bonamaisó, Santiago López-Begines ... Ana Méndez
The nucleotide sensing ability of IMPDH1 at the Bateman domain is regulated by light-dependent phosphorylation in the retina, to adjust GTP synthesis to illumination conditions.
Elucidating the contribution of augmented artificial skin-stretch stimulation to the fingertips to the immediate illusion of a higher stiffness and to an increased predictive grip force control.
Terren K Niethamer, Collin T Stabler ... Edward E Morrisey
Single-cell RNA sequencing reveals extensive endothelial cell (EC) heterogeneity throughout the lung vasculature and identifies two distinct populations, Car4-high ECs and proliferative ECs, that preferentially respond to lung injury.
Single-molecule immunoprecipitation method reveals that the high catalytic rate and multi-tasking capability make a concerted contribution to the strong signaling potency of the HER2-HER3 heterodimers.
Comprehensive, high-resolution lineage mapping of the fly brain reveals straightforward rules that drive neuronal complexity and probable evidence of brain evolution.
Amrutha Patkunarajah, Jeffrey H Stear ... Kate Poole
A novel mechanoelectrical transduction pathway can regulate the interactions of melanoma cells and their surrounding microenvironment, impacting both migration and cell dissociation from organotypic spheroids.
