Browse our Research Articles

An assay to assemble kinetochores de novo was developed and used to identify the role of the CENP-T pathway.

Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.

Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.

High resolution SthK channel cryo-EM structures in different ligand-bound states combined with single-channel functional data in the same conditions constrain a gating mechanism for CNG channels.

The structure of a voltage-activated potassium channel in lipid nanodiscs solved using cryo-electron microscopy is similar to previous X-ray structures, and provides insights into the mechanism of C-type inactivation.

A model for evolutionary inferences at both micro- and macroevolutionary scales is proposed and evaluated theoretically and through simulations.

The alpha-synuclein fibril structure reported here buries residues 50-57 at the interface between its two protofilaments, suggesting that familial Parkinson's disease associated mutations in these residues lead to a structure not compatible with the one presented here.

Structures of a mouse PCDH15 and LHFPL5 complex, two proteins involved in converting sound into electrical signals, illuminate how mechanical stimuli are delivered to the membrane of inner ear hair cells.

Integrin and actin associated proteins are resolved into four layers within myofibril attachments, an architecture requiring balanced positive and negative regulation of integrin adhesion with integrated mechanotransduction and actin pathways.

Cerebellar functional regions follow a gradual organization, which progresses from primary (motor) to transmodal (Default Mode Network) regions, and a secondary axis extends from task-unfocused to task-focused processing.