Browse our Research Articles

Page 990 of 1,403
    1. Neuroscience

    Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

    Jian Qiu, Heidi M Rivera ... Oline K Rønnekleiv
    Estrogen increases hypothalamic arcuate kisspeptin neuronal excitability and glutamate release to coordinate autonomic functions for maximizing reproductive success.
    1. Cancer Biology
    2. Cell Biology

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

    Ji Li, Peter S Choi ... William C Hahn
    Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.
    1. Epidemiology and Global Health

    Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure

    Isabel Rodriguez-Barraquer, Emmanuel Arinaitwe ... Bryan Greenhouse
    Analyses of detailed clinical and entomological data from cohort studies reveal how anti-parasite and anti-disease immunity against P. falciparum develop as a function of age and transmission intensity.
    1. Neuroscience

    Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies

    Efrén Álvarez-Salvado, Angela M Licata ... Katherine I Nagel
    A high-throughput behavioral paradigm and computational modeling are used to decompose olfactory navigation in walking Drosophila melanogaster into a set of quantitative relationships between sensory input and motor output.
    1. Neuroscience

    Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure

    Aitak Farzi, Jackie Lau ... Herbert Herzog
    CART exerts differential metabolic effects in response to activation of neurons of the Arc, where CART suppresses energy expenditure, while it enforces the reward characteristics of the LHA.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

    Melissa Kane, Stephanie V Rebensburg ... Paul D Bieniasz
    Comprehensive investigation reveals the variability and importance of the nuclear pore complex in HIV-1 infection and the activity of the antiretroviral protein, MX2.
    1. Neuroscience

    Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits

    Marios C Panayi, Simon Killcross
    The rodent orbitofrontal cortex makes functionally distinct contributions to flexible behavioural control, even within a single putative orbitofrontal subregion, which has important implications for establishing homology between rodent and primate orbitofrontal cortex.
    1. Cell Biology

    Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development

    Yubing Liu, Wei Zou ... Xiaochen Wang
    Embryonic development requires autophagy-dependent degradation of ribosomal RNAs.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Human axial progenitors generate trunk neural crest cells in vitro

    Thomas JR Frith, Ilaria Granata ... Anestis Tsakiridis
    Pluripotent stem cell differentiation provides insight into how neural crest subtypes of distinct axial identity are patterned in human embryos.
    1. Neuroscience

    MDN brain descending neurons coordinately activate backward and inhibit forward locomotion

    Arnaldo Carreira-Rosario, Aref Arzan Zarin ... Chris Q Doe
    A brain descending interneuron can coordinate a switch between two antagonistic behaviors (forward and backward locomotions).