Browse our Review Articles

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    1. Medicine

    Retinopathy of prematurity: Metabolic risk factors

    Zhongjie Fu, Anders K Nilsson ... Lois EH Smith
    An update for current knowledge gap in retinal metabolism after preterm birth and treatments for retinopathy of prematurity.
    1. Cell Biology

    Endosymbiotic selective pressure at the origin of eukaryotic cell biology

    Parth K Raval, Sriram G Garg, Sven B Gould
    All the characteristic traits of the eukaryotic cell, the basic unit of all macroscopic life, commenced to originate in a prokaryote as means to serve an endosymbiont today known as mitochondria.
    1. Medicine

    Extrachromosomal circular DNA: Current status and future prospects

    Yiheng Zhao, Linchan Yu ... Xiang Zhou
    Extrachromosomal circular DNA will hold great promise in future biomedical research and clinical translational application.
    1. Medicine

    A global view of the aspiring physician-scientist

    Christopher S Williams, W Kimryn Rathmell ... Mone Zaidi
    Challenges faced by the declining global workforce of young physician-scientists are highlighted, and a unified view on how to revive and reinvigorate this critical pool of dual-trained physicians worldwide is provided.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer genome and tumor microenvironment: Reciprocal crosstalk shapes lung cancer plasticity

    Siavash Mansouri, Daniel Heylmann ... Rajkumar Savai
    The crosstalk between cancer cell genomic features and the tumor microenvironment (TME) to reveal the impact of genetic alterations on the TME phenotype.
    1. Cell Biology
    2. Ecology

    Ecological lipidology

    Laura Christin Trautenberg, Marko Brankatschk ... Klaus Reinhardt
    Effects of dietary lipids on organismal function and reproductive fitness are persistent and may depend on lipid identity, cause the evolution of lipid-based diet choice, alter food webs, change species responses to environmental change, and affect human nutrition.
    1. Neuroscience

    Amygdala-cortical collaboration in reward learning and decision making

    Kate M Wassum
    A review of a neuronal circuit architecture that helps us to learn about rewarding events and then to use that information to support adaptive decision making.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination

    Andrea J Lund, Kristen J Wade ... Elizabeth J Carlton
    Genomic approaches can be integrated with epidemiological and ecological studies to provide high-resolution answers to open questions about schistosomiasis transmission dynamics, offering a level of precision that is actionable, such that schistosomiasis-control programming can be tailored to regional contexts.
    1. Cancer Biology

    Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata

    Michael Ohh, Cassandra C Taber ... Daniel Tarade
    Previous studies and emerging data on pseudohypoxic diseases suggest that the complex phenotypic spectrum of VHL disease is due to the extent of HIF pathway deregulation in susceptible cell types and not by other purported substrates or functions of pVHL.
    1. Computational and Systems Biology
    2. Ecology

    Data-driven causal analysis of observational biological time series

    Alex Eric Yuan, Wenying Shou
    Visualizations, simulations, and examples are used to provide an accessible synthesis of the reasoning and assumptions behind commonly used causal discovery approaches.