Browse our Review Articles

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    1. Developmental Biology
    2. Evolutionary Biology

    Gene expression mapping of the neuroectoderm across phyla – conservation and divergence of early brain anlagen between insects and vertebrates

    Nico Posnien, Vera S Hunnekuhl, Gregor Bucher
    Hypotheses on brain homologies between insects and vertebrates are tested by comparing gene expression patterns from flies and beetles with those from vertebrates at early neuroectoderm stages.
    1. Epidemiology and Global Health

    The importance of patient-partnered research in addressing long COVID: Takeaways for biomedical research study design from the RECOVER Initiative’s Mechanistic Pathways taskforce

    C Kim, Benjamin Chen ... RECOVER Mechanistic Pathways Task Force
    Collaborative and mutually beneficial patient-provider-researcher relationships are crucial in achieving success in understanding and treating long COVID.
    1. Developmental Biology
    2. Medicine

    Normal and dysregulated crosstalk between iron metabolism and erythropoiesis

    Yelena Ginzburg, Xiuli An ... Adam Goldfarb
    The expansion of our understanding about the regulation of iron metabolism, erythropoiesis, and the crosstalk between them has enabled delineating the pathophysiology of multiple diseases and provided rationale for novel therapeutic interventions.
    1. Neuroscience

    Enhancing precision in human neuroscience

    Stephan Nebe, Mario Reutter ... Gordon B Feld
    Measurement precision offers a comprehensive perspective on good scientific practices to improve reproducibility of research results by providing means to optimize design and analysis parameters (e.g. sample size, trial count, or sample heterogeneity) in accordance with the researcher’s goals.
    1. Developmental Biology
    2. Genetics and Genomics

    Breaking enhancers to gain insights into developmental defects

    Daniel A Armendariz, Anjana Sundarrajan, Gary C Hon
    Continuing advances in functional genomics will enable systematic characterization of how non-coding genetic variation at enhancers impacts developmental diseases.
    1. Cell Biology

    Searching for molecular hypoxia sensors among oxygen-dependent enzymes

    Li Li, Susan Shen ... Steven J Altschuler
    A survey of oxygen-dependent enzymes suggests new candidates for oxygen sensors, expanding potential mechanisms underlying hypoxia-related adaptations or diseases in humans.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A critical evaluation of protein kinase regulation by activation loop autophosphorylation

    Ronja Reinhardt, Thomas A Leonard
    Understanding protein kinase regulation by activation loop autophosphorylation depends on a critical assessment of experimental design, execution, and interpretation.
    1. Cell Biology

    Organization, functions, and mechanisms of the BBSome in development, ciliopathies, and beyond

    Xiaoyu Tian, Huijie Zhao, Jun Zhou
    Theoretical analysis of the current literature reveals the structural assembly, transport regulation, and molecular functions of the BBSome, emphasizing its roles in cilium-related processes.
    1. Cell Biology
    2. Computational and Systems Biology

    From actin waves to mechanism and back: How theory aids biological understanding

    Carsten Beta, Leah Edelstein-Keshet ... Arik Yochelis
    Mathematical methods reveal common underlying principles in diverse models of intracellular actin waves.
    1. Plant Biology

    Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?

    Yaron Caspi, Chrysoula K Pantazopoulou ... Kaisa Kajala
    Recent findings about the possible intercellular signalling role of glutamate, GABA, and melatonin might help to establish hypotheses concerning the evolutionary factors that caused intercellular organisms to use specific molecules in intercellular signalling.