An intelligent method is developed to morphologically classify platelet aggregates by agonist type, which potentially opens a window on novel clinical diagnostics and therapeutics of thrombotic disorders.
James M Mossner, Renata Batista-Brito ... Jessica A Cardin
Loss of function of the Rett syndrome gene MeCP2 in a small but powerful interneuron population, the VIP cells, causes a unique combination of impairments in neural function and behavior.
A combination of genetic fate-mapping and parabiotic experiments reveals the chronological expansion of yolk-sac-derived renal tissue-resident macrophages with age by cellular proliferation and recruitment from circulating progenitors.
Current evidence does not suggest adverse effects of ACE inhibitors or ARBs in COVID-19 patients and, to the contrary, discontinuing these drugs in these patients may potentially be harmful.
Eliminating the calcium-binding protein Doc2b does not alter transmission at a mature synapse under physiological conditions, counter to the prevailing view of Doc2b based on cultured neurons.
Computational analyses quantitatively account for optical refraction at air-water interfaces to enable visual neuroscientists to present distortion-free stimuli to underwater animals.
Tracy L McGregor, Karen A Hunt ... David A van Heel
Lifelong HAO1 knockout was safe and without clinical phenotype in an identified healthy woman, de-risking a rare disease therapeutic approach through the power of naturally occurring human genetic variation.
