Browse our Tools and Resources

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    1. Computational and Systems Biology
    2. Evolutionary Biology

    Fast and flexible estimation of effective migration surfaces

    Joseph Marcus, Wooseok Ha ... John Novembre
    Fast and flexible estimation of effective migration surfaces (FEEMS) is a new statistical method that can quickly infer and visualize patterns of migration from genetic data with spatial coordinates.
    1. Epidemiology and Global Health

    FnCas9-based CRISPR diagnostic for rapid and accurate detection of major SARS-CoV-2 variants on a paper strip

    Manoj Kumar, Sneha Gulati ... Debojyoti Chakraborty
    A newly developed lateral flow assay can diagnose mutational signatures of major SARS CoV-2 variants in a rapid, inexpensive, and sequence-free manner.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data

    Oliver Stirrup, Joseph Hughes ... Judith Breuer
    Epidemiological and viral sequence data can be combined to provide standardised feedback on cases of hospital onset COVID-19 infection that would be useful for infection prevention and control.
    1. Microbiology and Infectious Disease

    Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

    Rodrigo M Young, Camila J Solis ... Luis A Quiñones
    PCR testing for SARS-CoV-2 from samples taken from smartphone screens, Phone Screen Testing, provides a sensitive, cost-effective, simple, and non-invasive new method that could boost COVID-19 mass test screening.
    1. Cell Biology
    2. Developmental Biology

    Single-cell RNA-seq analysis reveals penaeid shrimp hemocyte subpopulations and cell differentiation process

    Keiichiro Koiwai, Takashi Koyama ... Ryuji Kawano
    Single-cell mRNA sequencing on hemocytes of penaeid shrimp revealed six types of hemocytes, type markers, differentiation pathways, and different immune roles among these subpopulations based on their transcriptional profiles.
    1. Structural Biology and Molecular Biophysics

    Locating macromolecular assemblies in cells by 2D template matching with cisTEM

    Bronwyn A Lucas, Benjamin A Himes ... Nikolaus Grigorieff
    2D template matching complements 3D template matching of tomograms, providing fast and specific detection of molecules in cryo-EM images of cells, as well as generating 3D reconstructions from detected targets.
    1. Cell Biology
    2. Neuroscience

    High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

    Haining Zhong, Cesar C Ceballos ... Tianyi Mao
    A high-fidelity and efficient strategy to use CRISPR/Cas9 to reversibly insert large DNA fragments into somatic cells to label or modify endogenous proteins for research and, in the future, for gene therapy.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin, Eleanor Johns ... Richard M White
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Detecting adaptive introgression in human evolution using convolutional neural networks

    Graham Gower, Pablo Iáñez Picazo ... Fernando Racimo
    Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
    1. Neuroscience

    Introduction to the EQIPD quality system

    Anton Bespalov, René Bernard ... Thomas Steckler
    A system has been developed that supports generation of reliable basic biomedical research data while being open-access and lean with no negative impact on freedom of scientific exploration.