Browse our Tools and Resources

Page 32 of 88
    1. Neuroscience

    Double-μPeriscope, a tool for multilayer optical recordings, optogenetic stimulations or both

    Mototaka Suzuki, Jaan Aru, Matthew E Larkum
    Interactions between near but distinct (<1 mm) structures such as cortical layers in the rodent brain can be studied by a new micro-optical tool that is low-cost and capable of multilayer optical recordings, optogenetic stimulations, or both.
    1. Biochemistry and Chemical Biology

    Assessing target engagement using proteome-wide solvent shift assays

    Jonathan G Van Vranken, Jiaming Li ... Steven P Gygi
    Solvent shift assays such as solvent proteome profiling and solvent-PISA are valuable tools for identifying protein-ligand interactions on a proteome-wide scale and can be used to determine drug target engagement, which should benefit future drug discovery efforts.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Framework for rapid comparison of extracellular vesicle isolation methods

    Dmitry Ter-Ovanesyan, Maia Norman ... David R Walt
    Measuring surface proteins on extracellular vesicles enables quantitative comparison of different isolation methods and optimization of size exclusion chromatography.
    1. Neuroscience

    A 3D adult zebrafish brain atlas (AZBA) for the digital age

    Justin W Kenney, Patrick E Steadman ... Paul W Frankland
    A new tool for three-dimensional exploration of adult zebrafish neuroanatomy.
    1. Neuroscience

    The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Cristina Segalin, Jalani Williams ... Ann Kennedy
    The Mouse Action Recognition System is a computational pipeline for automated classification of social behaviors in freely interacting mice, accompanied by a graphical interface for analysis of multimodal neuroscience datasets.
    1. Neuroscience

    A parameter-free statistical test for neuronal responsiveness

    Jorrit S Montijn, Koen Seignette ... J Alexander Heimel
    A simple and robust statistical test for neuronal stimulus response, that outperforms PSTH-based approaches such as t-tests and ANOVAs.
    1. Neuroscience

    Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei

    Zhengchao Xu, Zhao Feng ... Anan Li
    Whole-brain quantitative input-output circuits of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei were mapped using viral tracing and high-resolution optical imaging.
    1. Neuroscience

    Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

    Minh Q Nguyen, Lars J von Buchholtz ... Steve Davidson
    Single-nucleus transcriptomics exposes unique features of human somatosensory neurons and clues that may help resolve repeated problems in translating new experimental approaches for treating pain.
    1. Neuroscience

    Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

    Austin R Graves, Richard H Roth ... Richard L Huganir
    A knockin mouse line was made to label endogenous AMPA receptors, enabling direct observation of synaptic plasticity in behaving animals with single-synapse resolution across the entire brain.
    1. Cell Biology
    2. Ecology

    Monitoring single-cell dynamics of entry into quiescence during an unperturbed life cycle

    Basile Jacquel, Théo Aspert ... Gilles Charvin
    A switch-like cell fate divergence revealed by continuous single-cell tracking during entry into quiescence.