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Page 31 of 89
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling

    Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
    iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.
    1. Developmental Biology
    2. Genetics and Genomics

    A low-tech, cost-effective and efficient method for safeguarding genetic diversity by direct cryopreservation of poultry embryonic reproductive cells

    Tuanjun Hu, Lorna Taylor ... Michael J McGrew
    A simple cryopreservation method using chicken eggs will be a valuable tool to safeguard genetic diversity and conserve the 1600 local breeds of chicken on the planet.
    1. Neuroscience

    The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain

    Hui Zhang, Haifang Wang ... Jie He
    Single-cell transcriptomes of larval zebrafish whole brain shed light on the multidimensional landscapes of transcription factors and post-transcriptional regulators in vertebrate whole-brain neuronal classification and revealed principles of how neuronal cell diversity develops and evolves.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Generation and diversification of recombinant monoclonal antibodies

    Keith F DeLuca, Jeanne E Mick ... Jennifer G DeLuca
    Tools and methodologies to create and diversify recombinant antibodies and antibody fragments provide researchers with the ability to generate low-cost, high-yield immunological reagents.
    1. Cell Biology
    2. Genetics and Genomics

    Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells

    Giulia Ambrosi, Oksana Voloshanenko ... Michael Boutros
    Bi-allelic tagging enables the biophysical analysis of oncogenic β-catenin genetic variants in Wnt signaling.
    1. Genetics and Genomics

    Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria

    Athina Georgiadou, Claire Dunican ... Aubrey J Cunnington
    Comparative transcriptomics of whole blood can be used to evaluate the systemic host response and its concordance between human and mouse malaria and aid the selection of appropriate models for translational malaria research.
    1. Developmental Biology

    Tracking cell lineages in 3D by incremental deep learning

    Ko Sugawara, Çağrı Çevrim, Michalis Averof
    Incremental deep learning enables accurate tracking of cell lineages in 3D with a modest investment in time and effort.
    1. Cell Biology

    Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes

    Michelina Kierzek, Parker E Deal ... Christoph Brenker
    FASTM is a novel technique that leverages phase-sensitive signal detection for time-resolved multiplexing of probes with millisecond time resolution, opening new opportunities for interrogating rapid cellular signaling and (bio)chemical reactions.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

    Jugal Mohapatra, Kyuto Tashiro ... Glen Liszczak
    A technology to produce homogenously poly-ADP-ribosylated proteins reveals key molecular mechanisms that govern ATP-dependent chromatin remodeling activity at DNA damage sites.
    1. Neuroscience

    A naturalistic environment to study visual cognition in unrestrained monkeys

    Georgin Jacob, Harish Katti ... SP Arun
    A novel naturalistic environment with a touchscreen enables high-quality eye tracking for studying visual cognition in monkeys, and allows naive monkeys to learn complex tasks through a combination of social observation of trained monkeys and trial-and-error learning.