Browse our Tools and Resources

Page 31 of 92
    1. Developmental Biology
    2. Plant Biology

    Using positional information to provide context for biological image analysis with MorphoGraphX 2.0

    Sören Strauss, Adam Runions ... Richard S Smith
    MorphoGraphX is a user-friendly image processing software primarily aimed at segmenting 3D biological images into cells, quantifying cellular gene expression and growth, and understanding these data in the spatial context of developing organs.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcription elongation is finely tuned by dozens of regulatory factors

    Mary Couvillion, Kevin M Harlen ... L Stirling Churchman
    NET-seq analysis of 41 S. cerevisiae transcription regulatory factors uncovers their differential and opposing effects on Pol II transcription elongation and antisense transcription, revealing that wild-type transcription is balanced by the joint impact of many regulators.
    1. Neuroscience

    A dynamic clamp protocol to artificially modify cell capacitance

    Paul Pfeiffer, Federico José Barreda Tomás ... Susanne Schreiber
    Via the capacitance clamp, electrophysiologists can for the first time flexibly set an artificial membrane capacitance for neurons and other excitable cells and thereby adjust their membrane time constant independent of any conductance changes.
    1. Computational and Systems Biology
    2. Ecology

    The LOTUS initiative for open knowledge management in natural products research

    Adriano Rutz, Maria Sorokina ... Pierre-Marie Allard
    The LOTUS initiative builds, through the Wikidata knowledge graph, a virtuous cycle of data sharing practices for natural products research.
    1. Neuroscience

    Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography

    Mingchao Yan, Wenwen Yu ... Zheng Wang
    A comprehensive excitatory projectome of the ventro-lateral prefrontal cortex in macaques was generated by using viral tracing integrated with serial two-photon tomography and diffusion tractography, thus providing new evidence of rejecting the monosynaptic connection of inferior fronto-occipital fasciculus in monkeys.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A transcriptomic atlas of Aedes aegypti reveals detailed functional organization of major body parts and gut regional specializations in sugar-fed and blood-fed adult females

    Bretta Hixson, Xiao-Li Bing ... Nicolas Buchon
    RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation

    Noushin Hadadi, Martina Spiljar ... Mirko Trajkovski
    Integrative analysis of multi-tissue transcriptomics data of mice subjected to cold, mild warm or room temperature places the thermal adaptation of individual tissues in a whole-organism perspective.
    1. Genetics and Genomics
    2. Neuroscience

    Machine learning sequence prioritization for cell type-specific enhancer design

    Alyssa J Lawler, Easwaran Ramamurthy ... Andreas R Pfenning
    A new cross-species machine learning-based strategy is applied to find enhancers that specifically label parvalbumin neurons in the mouse and macaque.
    1. Neuroscience

    Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

    Vasiliki-Ilya Gargareta, Josefine Reuschenbach ... Hauke B Werner
    Comparing humans and mice, the protein composition of central nervous system myelin and the transcriptional profiles of myelin-producing oligodendrocytes are largely similar with respect to abundant structural myelin constituents but show divergent expression of a range of other distinct genes.
    1. Microbiology and Infectious Disease

    A novel lineage-tracing mouse model for studying early MmuPV1 infections

    Vural Yilmaz, Panayiota Louca ... Katerina Strati
    A novel mouse model which permits tracking of papillomavirus infected cells in mouse stratified epithelia during early infection by means of genetic reporter activation.