Genomic neighborhood signatures delineate catalytic versus putative regulatory CODH clades, establishing a framework for predicting enzyme functionality and guiding discovery of biocatalysts for CO2 reduction.
Frederick A Matsen IV, Will Dumm ... Hugh K Haddox
Factoring out nucleotide-level mutation biases from antibody language models dramatically improves prediction of functional mutation effects while reducing computational cost by orders of magnitude.
Direct presynaptic patch-clamp recording and fluorescent imaging of the vesicular release demonstrate that a non-canonical cannabinoid receptor GPR55 deprives readily releasable vesicles of competency in cerebellar Purkinje cell axons.
François Simon, Guillaume Ramadier ... Lucien E Weiss
Exatrack is a framework for analyzing Brownian, directed, and confined motion using a hidden-variable probabilistic model to extract physical insight into particle diffusion.
Transcriptomic heterogeneity in infective-stage surface proteins of Trypanosoma cruzi, particularly trans-sialidase-like superfamily members, suggests distinct expression profiles among individual parasites that may enhance immune evasion and infection adaptability.
Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modification.
