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Two families of ubiquitin ligases secreted by the intracellular pathogen Legionella pneumophila utilize distinct chemistries to form a stable, ubiquitin-rich structure around the vacuole, which is subsequently disassembled as infection progresses.

A comprehensive investigation of extracellular asparagine utilization highlights its role as a critical regulator of murine CD4+ T cell activation, differentiation, and function.

Deficiency in any of the interdependent C2a proteins (CCDC108, MYCBPAP, and CFAP70) collapses this central pair microtubule-associated projection, disrupting vertebrate ciliary movement, and causing primary ciliary dyskinesia phenotypes in mice.

The yeast mitochondrial malate dehydrogenase–citrate synthase metabolon is a dynamic multienzyme complex that continuously assembles and disassembles in response to respiratory activity, mitochondrial matrix pH, and substrate abundances.

Medial prefrontal cortex activity is not required for learning or execution of adaptive avoidance behavior, despite encoding select task features.

Lenacapavir disrupts HIV-1 capsid elasticity, inducing mechanical rupture at the nuclear pore, highlighting that altering viral material properties can be a viable antiviral drug design strategy.

Working memory alternates between remembered items in a rhythmic theta cycle.

Celldetective is an open-source software integrating segmentation, tracking, and event detection to perform high-throughput end-to-end study of dynamic cell interactions, without requiring coding skills, demonstrated on microscopy immunological assays.