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Page 19 of 1,888
    1. Structural Biology and Molecular Biophysics

    PPIscreenML is a method for structure-based screening of protein-protein interactions using AlphaFold

    Victoria Mischley, Johannes Maier ... John Karanicolas
    PPIscreenML is a rigorously benchmarked method that uses AlphaFold2 to screen for interacting protein pairs, and it provides superior performance to other available methods.
    1. Cell Biology

    Prior cocaine use disrupts identification of hidden states by single units and neural ensembles in orbitofrontal cortex

    Wenhui Zong, Lauren Mueller ... Geoffrey Schoenbaum
    Rats with a history of cocaine use exhibited prolonged encoding of idiosyncratic task features in orbitofrontal cortex and a reduced ability to compress such features to identify underlying hidden states.
    1. Cell Biology

    Orderly mitosis shapes interphase genome architecture

    Krishnendu Guin, Adib Keikhosravi ... Tom Misteli
    High-throughput CRISPR-KO imaging screens reveal that disruption of mitotic processes impairs spatial genome organization in daughter cells.
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development

    Vivek Bhardwaj, Alberto Griffa ... Alexander van Oudenaarden
    A robust and quantitative map links chromatin modification and gene expression of cells during zebrafish embryogenesis.
    1. Developmental Biology
    2. Evolutionary Biology

    The endoderm cell trajectory of urochordate Styela clava reveals the dual developmental origin and evolution of digestive tract

    Yonghang Ge, Wei Zhang ... Jiankai Wei
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation

    Gustavo Aguilar, Michèle Sickmann ... Martin Müller
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Compelling
    1. Chromosomes and Gene Expression

    mRNA Imprinting: transcription apparatus can remotely control cytoplasmic post-transcriptional mechanisms by dozens of proteins

    Shira Urim, Artyom Artamov ... Mordechai Choder
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Cellular basis of accelerated whole-tooth regeneration

    Talha Mubeen, Haowen He ... Jeffrey T Streelman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Screening the MMV Pathogen Box reveals the mitochondrial bc1-complex as a drug target in mature Toxoplasma gondii bradyzoites

    Deborah Maus, Elyzana Putrianti ... Martin Blume
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Evolutionary Biology

    New insights into the evolution of spider silk proteins illuminated by long-read transcriptomes

    Kesen Zhu, Shiyi Zhou ... Hui Xiang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
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