A vessel on a chip microfluidic device recapitulates the main features of meningococcal vascular colonization, providing high time and space microscopy resolution of the infection process in 3D.
Loss of endothelial Slit2 removes the chemo-attractive signal needed for Robo1-positive sympathetic axons to follow coronary vessels, resulting in reduced ventricular innervation.
Extracellular adenosine deamination by ADGF generates ammonia that directs tip organizer development, revealing a conserved metabolic mechanism linking nucleotide turnover to developmental regulation.
Ripples maintain time-locked occurrence across the septo-temporal axis and hemispheres while showing local phase coupling, revealing a dual mode of synchrony in CA1 network dynamics.
Genes steadily associated with prognosis define conserved mitotic and immune programs that robustly predict cancer patient survival and therapeutic resistance across tumor types.
