GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.
Encoding individual behavioral traits into a low-dimensional latent representation enables the accurate prediction of decision-making patterns across distinct task conditions.
Formation and stability of endocytic receptor-arrestin complexes during clathrin-mediated endocytosis are governed by phosphorylation-dependent arrestin-AP2 interactions.
Targeted computational redesign of an IL-7 superkine with enhanced folding efficiency and receptor affinity demonstrates superior immune-stimulatory and antitumor activity over wild-type IL-7.
