Browse the latest research

Page 19 of 1,853
    1. Microbiology and Infectious Disease

    Niche exclusion of a lung pathogen in mice with designed probiotic communities

    Kelsey E Hern, Ashlee M Phillips ... Adam P Arkin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex

    Sohrab Salimian, Harrison A Grier, Matthew T Kaufman
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    High-Fidelity Neural Speech Reconstruction through an Efficient Acoustic-Linguistic Dual-Pathway Framework

    Jiawei Li, Chunxu Guo ... Yuanning Li
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Physics of Living Systems

    Postural adaptations may contribute to the unique locomotor energetics seen in hopping kangaroos

    Lauren Thornton, Taylor Dick ... Christofer J Clemente
    Postural adjustments that reduce ankle leverage in kangaroos enhance tendon stress and elastic energy storage at higher speeds, providing energetic efficiency during hopping but potentially constraining the maximum size achievable by large species.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Exploiting fluctuations in gene expression to detect causal interactions between genes

    Euan Joly-Smith, Mir Mikdad Talpur ... Andreas Hilfinger
    Analyzing stochastic cell-to-cell variability can potentially reveal causal interactions in gene regulatory networks.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes

    Yury S Bykov, Solene Zuttion ... Maya Schuldiner
    Combined with high-throughput yeast genetics, a split green fluorescent protein encoded directly in the mitochondrial DNA helps to identify targeting signals and functions of dually localized proteins.
    1. Neuroscience

    Strikingly different neurotransmitter release strategies in dopaminergic subclasses

    Ana Dorrego-Rivas, Darren J Byrne ... Matthew S Grubb
    Different locations of neurotransmitter release sites in axon-bearing and anaxonic olfactory bulb dopaminergic neurons allow self-inhibition only in anaxonic cells, showing how polarity differences create separate functional roles in sensory processing.
    1. Cancer Biology

    Transcriptional subtypes on immune microenvironment and predicting postoperative recurrence and metastasis in human pheochromocytoma and paraganglioma

    Yang Liu, Xu Yan ... Lingyu Li
    Distinct transcriptional subtypes in PPGLs link molecular programs with immune context, providing biomarkers for recurrence risk and therapeutic targeting.
    1. Cancer Biology

    Endoscopic liquid biopsies of gastric fluid in a large human patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer

    Francine C Cadoná, Thais F Bartelli ... Emmanuel Dias-Neto
    Elevated gfDNA supports gastric cancer diagnosis and may guide management when combined with tissue biopsies, and in established cancer, higher gfDNA may predict better outcomes, potentially indicating immune-cell infiltration.
    1. Cell Biology

    The fate of pyruvate dictates cell growth by modulating cellular redox potential

    Ashish G Toshniwal, Geanette Lam ... Jared Rutter
    Pyruvate dictates redox balance and cell size, establishing metabolism as a dominant regulator of cellular fitness, unveiling new strategies to modulate cancer, regeneration, and diabetes.
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