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Identification of mangostins as potent BK channel activators links natural xanthones to vascular smooth muscle relaxation, providing a mechanistic basis for their reported antihypertensive effects.

A fully computationally designed SaCas9 variant expands PAM recognition to NNNRRT, achieving up to 116-fold higher editing at noncanonical sites while matching the performance of experimentally evolved variants.

Contrary to prior work, principal axes of structural and functional connectivity are established early in life, remaining stable and undergoing refinement throughout development.

The first all-atom models of the mycobacterial outer membrane reveal how lipid organization and asymmetry generate a structurally heterogeneous barrier that underlies its unique permeability properties.

Multi-omic and bioenergetic profiling in a HER2-driven mouse model of mammary cancer reveals that reduced mitochondrial content does not limit tumor respiratory capacity, which is instead dramatically elevated compared to benign mammary tissue.

Continuous flash suppression reduces V1 orientation responses in an ocular-dominance-dependent manner, which may still allow low-level coarse orientation discrimination but provide insufficient information for higher-level visual and cognitive tasks.