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Bulding a cardiolipin binding site into a computationally designed transmembrane protein uncovers how proteins can recognize specific lipids and use them to regulate their function.

Phosphoproteomics identifies diverse CaM kinase substrates, while genetic dissection reveals an unexpected antagonistic interaction with calcineurin signaling that operates in distinct neurons to regulate thermo-nociception in Caenorhabditis elegans.

Transcriptional regulatory network models can aid in identifying candidate genes associated with the target phenotype in bacterial genome-wide association studies.

Muscle contraction forces shape tenocyte gene expression, with sequencing and spatial analyses revealing unique force-dependent gene regulation patterns, suggesting tenocytes fine-tune tendon matrix in response to varied mechanical cues.