Browse the latest research

Page 19 of 1,861
    1. Genetics and Genomics

    Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment

    Nicholas Tolman, Taibo Li ... Simon WM John
    Single-cell transcriptomics identifies three discrete mouse trabecular meshwork subtypes and demonstrates that an Lmx1b glaucoma mutation drives mitochondrial dysfunction and elevated intraocular pressure, which is lessened by vitamin B3 supplementation.
    1. Genetics and Genomics

    Reproducibility of Scientific Claims in Drosophila Immunity: A Retrospective Analysis of 400 Publications

    Hannah Westlake, Fabrice David ... Bruno Lemaitre
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    • Incomplete
    1. Cell Biology

    Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

    Yunpo Zhao, Jianli Duan ... Zhe Han
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
    1. Developmental Biology

    Progressive mural cell deficiencies across the lifespan in a foxf2 model of Cerebral Small Vessel Disease

    Merry Faye E Graff, Emma EM Heeg ... Sarah J Childs
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    A retrospective analysis of 400 publications reveals patterns of irreproducibility across an entire life sciences research field

    Joseph Lemaitre, Désirée Popelka ... Bruno Lemaitre
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Structural Biology and Molecular Biophysics

    Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

    Kexin Zhang, Timothy Grant, Nikolaus Grigorieff
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration

    Ravi Kumar, Simon Couly ... Ashish Lal
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    GMCL1 controls 53BP1 stability and modulates taxane sensitivity

    Yuki Kito, Tania J González-Robles ... Michele Pagano
    GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.
    1. Structural Biology and Molecular Biophysics

    A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

    Ivana Petrovic, Samit Desai ... Stephan Grzesiek
    Formation and stability of endocytic receptor-arrestin complexes during clathrin-mediated endocytosis are governed by phosphorylation-dependent arrestin-AP2 interactions.
    1. Computational and Systems Biology
    2. Neuroscience

    Predicting human decision-making across task conditions via individuality transfer

    Hiroshi Higashi
    Encoding individual behavioral traits into a low-dimensional latent representation enables the accurate prediction of decision-making patterns across distinct task conditions.
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