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    1. Cell Biology

    Transcriptomic profiling of Schlemm’s canal cells reveals a lymphatic-biased identity and three major cell states

    Revathi Balasubramanian, Krishnakumar Kizhatil ... Simon WM John
    A comprehensive molecular characterization of Schlemm’s canal cells to date provides a wealth of molecular details.
    1. Neuroscience

    Direct observation of the neural computations underlying a single decision

    Natalie Steinemann, Gabriel M Stine ... Michael N Shadlen
    Simultaneous recording from many neurons in macaque lateral intraparietal area reveals the elusive drift-diffusion signal, long suspected to underlie individual perceptual decisions and response times.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants

    Alon Avraham Ginatt, Maria Berihu ... Shiri Freilich
    Understanding metabolic interactions and successive cross-feeding in native microbiomes illuminates the mechanisms behind plant disease promotion and suppression, enhancing our ability to manipulate microbiomes toward specific functions of interest.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Extreme positive epistasis for fitness in monosomic yeast strains

    Hanna Tutaj, Katarzyna Tomala ... Ryszard Korona
    Monosomy in yeast results in numerous gene dosage insufficiencies with potentially lethal collective effect, but strong positive epistasis rooted in the modular structure of cell metabolism cancels it.
    1. Genetics and Genomics

    Expression of most retrotransposons in human blood correlates with biological aging

    Yi-Ting Tsai, Nogayhan Seymen ... Mohammad M Karimi
    Despite no observed correlation between retrotransposon (RTE) activity and chronological age, the expression of most RTE classes and families except SINEs correlated with biological age-associated gene signature scores.
    1. Computational and Systems Biology
    2. Neuroscience

    White matter structural bases for phase accuracy during tapping synchronization

    Pamela Garcia-Saldivar, Cynthia de León ... Hugo Merchant
    Comparison between tapping performance of humans during a synchronization task and new metrics that characterize the U-fiber system of white matter revealed large intersubject correlations between phase accuracy at specific tempos and the strength of connectivity in their audiomotor system.
    1. Evolutionary Biology

    Coenzyme-Protein Interactions since Early Life

    Alma Carolina Sanchez-Rocha, Mikhail Makarov ... Klára Hlouchová
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    The recombination landscape of introgression in yeast

    Enrique J Schwarzkopf, Nathan Brandt, Caiti Smukowski Heil
    Revised
    Reviewed Preprint v2
    Updated
    • Inadequate
    1. Ecology

    Range geographies, not functional traits, explain convergent range and phenology shifts under climate change

    Catherine Sirois-Delisle, Susan CC Gordon, Jeremy T Kerr
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Intestinal microbiome dysbiosis increases Mycobacteria pulmonary colonization in mice by regulating the Nos2-associated pathways

    MeiQing Han, Xia Wang ... Fan Yang
    Gut microbiota dysbiosis increased Nos2 expression through the 'gut–lung axis', and altered intracellular antimicrobial and anti-inflammatory environment by abnormal NO, ROS, and Defb1, thereby promoting Mycobacteria colonization in mouse lungs.
    Version of Record
    Research Article
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