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DNL343, a brain-penetrant integrated stress response inhibitor, reduces neurodegeneration in mouse models and identifies biomarker candidates for assessing treatment responses in clinical settings.

OsNF-YB7, an ortholog of Arabidopsis LEC1, is a negative regulator of Chl biosynthesis in rice embryos by interacting with OsGLK1 to inhibit the transactivity of OsGLK1.

Synaptic glutamate release is potentiated by short metabolic failure whereas longer durations of energy depletion lead to a postsynaptic failure of synaptic transmission.

Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for baseline breathing and hypercapnic, hypoxic chemosensory reflexes, which challenges the current understanding of central noradrenergic neurons in breathing control.

Prominin 1 and Tweety Homology 1, two proteins that regulate membrane shape in neural and neuroepithelial cells, have shared evolutionary history and both cause cells to secrete extracellular vesicles.

Complementing experimental data from EPR spectroscopy with computational modeling techniques provides access to protein structural dynamics and enables the characterization of rare protein conformations.

PPI-hotspot^ID, trained using an automated machine-learning framework, AutoGluon, on the largest PPI-hot spot dataset to date, detects hot spots beyond protein–protein interfaces, uncovering druggable interactions to aid design of PPI-modulating therapeutics.

For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.