Transmissible tumors in Hydra can manipulate host phenotype by inducing the growth of supernumerary tentacles, enhancing host foraging efficiency and promoting tumor vertical transmission, akin to manipulative parasites.
Newly produced genomic data, as well as available datasets, reveal the pathogen's global transmission history along with the live poultry trade and pinpoint mobile element-driven local Salmonella adaptation.
Agnieszka Glica, Katarzyna Wasilewska ... Katarzyna Jednoróg
Findings challenge the neural noise hypothesis of dyslexia, showing no differences in excitatory/inhibitory balance between individuals with dyslexia and controls.
Attenuation of viral Nef-driven PI3 kinase signaling in B cells precedes the induction of neutralizing antibody responses against a difficult-to-neutralize simian immunodeficiency virus.
Prostaglandin E2 inhibits Kv2.2 channels via the EP2/4-PKA signaling pathway, leading to decreased glucose-stimulated action potential firing and insulin secretion in normal pancreatic β-cells.
Mathematical models of horizontal gene transfer reveal the determinants underlying multistability of microbial communities, offering key insights for the predictive control and engineering of complex microbiota.
A combination of polymer physics theories consistently rationalizes comprehensive experimental effects of salt, ATP, phosphorylation, and sequence charge and arginine/lysine patterns on the reentrant phase behaviors of intrinsically disordered proteins.
Cristina Paissoni, Sarita Puri ... Carlo Camilloni
Computational modeling and in vitro experiments identify a unique conformational state in amyloidogenic light chains, providing a structural basis for amyloidosis and a precise target for drug design.
