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Page 299 of 1,780
    1. Ecology

    Synthetic eco-evolutionary dynamics in simple molecular environment

    Luca Casiraghi, Francesco Mambretti ... Tommaso Bellini
    A variant of SELEX introduced here to induce abiotic evolution in a molecular system enables to observe and study speciation, the nature of fitness, and the interplay between use of resources and interactions between individuals.
    1. Evolutionary Biology

    Emergence of catalytic function in prebiotic information-coding polymers

    Alexei V Tkachenko, Sergei Maslov
    Theoretical scenario for prebiotic polymers capable of nonenzymatic replication to acquire an early catalytic function, specifically cleavage activity.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presence

    Monica Salinas-Pena, Elena Rebollo, Albert Jordan
    Imaging analysis confirms ChIP-Seq data on the distinct genomic distribution of histone H1 variants in AT-rich, nuclear peripheral regions (H1.2, H1.3, H1.5, H1.0) or GC-rich, throughout the nucleus (H1.4, H1X).
    1. Cancer Biology
    2. Computational and Systems Biology

    A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

    Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
    A robust machine learning diagnostic platform utilizing exosome proteins to distinguish various human cancers in diverse biological fluids.
    1. Neuroscience

    Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

    Hideo Hagihara, Hirotaka Shoji ... Tsuyoshi Miyakawa
    Brain lactate and pH changes, identified as common features in diverse neuropsychiatric animal models, may represent transdiagnostic endophenotypes associated with cognitive impairment.
    1. Physics of Living Systems

    Hydrodynamics and multiscale order in confluent epithelia

    Josep-Maria Armengol-Collado, Livio Nicola Carenza, Luca Giomi
    Confluent cellular layers display the remarkable ability of supportingmultiscale orientational order, that is the existence of different typeof liquid crystal order at different length scales.
    1. Structural Biology and Molecular Biophysics

    Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein

    Zhongying Han, Sabrina Panhans ... Thorben Cordes
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Neuroscience

    Dopamine lesions alter the striatal encoding of single-limb gait

    Long Yang, Deepak Singla ... Sotiris C Masmanidis
    Striatal neurons preferentially fire at specific phases of the gait cycle, and the strength of gait encoding is selectively increased in indirect pathway neurons following dopamine lesions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

    Yuting Zhang, Min Zhang ... Guojiang Chen
    A novel antibody recognizing receptor-binding region of MARV glycoprotein was developed and displays broad-spectrum neutralizing activity to filovirus species when NPC2 was fused to the N-terminus of the mAb.
    1. Cell Biology

    A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit

    Damien Laporte, Aurelie Massoni-Laporte ... Isabelle Sagot
    In quiescent yeast, a stable bundle of parallel microtubules is assembled from the centrosome by an original multistep mechanism that follows a precise temporality and involves Aurora B and various kinesins.