Browse the latest research

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    1. Cell Biology
    2. Medicine

    Uncovering Shared and Tissue-Specific Molecular Adaptations to Intermittent Fasting in Liver, Brain, and Muscle

    Yibo Fan, Senuri De Silva ... Thiruma V Arumugam
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Complex opioid driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward and addiction

    Ramesh Chittajallu, Anna Vlachos ... Chris J McBain
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology

    Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring

    Nobumichi Takamatsu, Hiroko Furumoto ... Kumiko Hayashi
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Distinct waves of ovarian follicles contribute to mouse oocyte production

    Qi Yin, Allan C Spradling
    The first follicle wave undergoes atresia to amplify androgen-producing theca cells, while previously unknown wave 1.5 follicles leave quiescence at 2 weeks and produce most of the earliest offspring.
    1. Neuroscience

    Social experience shapes fighting strategies in Drosophila

    Can Gao, Mingze Ma ... Yufeng Pan
    Social enrichment increases the less-frequent high-intensity aggressive tussling and decreases the low-intensity aggressive lunging via distinct sensory and central neurons.
    1. Plant Biology

    Structure-guided secretome analysis of gall-forming microbes offers insights into effector diversity and evolution

    Soham Mukhopadhyay, Muhammad Asim Javed ... Edel Perez-Lopez
    Comparative structural genomics identifies unique effector architectures and ankyrin-mediated host targeting, revealing central and conserved strategies that underpin the pathogenicity of diverse gall-forming microbial species across evolutionary lineages.
    1. Physics of Living Systems

    Balancing stability and flexibility when reshaping archaeal membranes

    Miguel Amaral, Felix Frey ... Anđela Šarić
    Archaeal cells mix single-headed and double-headed lipids to construct resilient but flexible membranes to help them survive in extreme environments.
    1. Neuroscience

    A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex

    Cecilia Hes, Abigail J Tomlinson ... Paul V Sabatini
    The dorsal vagal complex is a highly intricate structure composed of distinct transcriptional classes of glial and neuronal cells, exhibiting many similarities but also notable differences between mice and rats.
    1. Structural Biology and Molecular Biophysics

    DIRseq as a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences

    Matt MacAinsh, Sanbo Qin, Huan-Xiang Zhou
    A sequence-based method, DIRseq, has been developed to predict drug-interacting residues of intrinsically disordered proteins.
    1. Neuroscience

    Distributed subthreshold representation of sharp wave-ripples by hilar mossy cells

    Ayako Ouchi, Taro Toyoizumi ... Yuji Ikegaya
    Machine learning with whole-cell patch-clamp and local field potential recordings reveals that synaptic responses from five mossy cells, despite their limited population, can significantly reconstruct about 30% of the total hippocampal sharp wave-ripples, highlighting efficient distributed coding within subthreshold activities.