A novel strategy to combat antimicrobial resistance has been identified by using vaccines and nanobodies to target specific extracellular proteins located on multiresistant bacterial plasmids.
Trine Line Hauge Okholm, Andreas Bjerregaard Kamstrup ... Christian Kroun Damgaard
A dysregulated circular RNA in bladder cancer controls oncogenic pathways by tethering specific RNA-binding proteins, which in turn inhibits their normal functions.
Simon M Lichtinger, Joanne L Parker ... Philip C Biggin
The manner in which protons control the conformational behaviour of mammalian peptide transporters is revealed through state-of-the-art molecular dynamics simulations supported by cell-based assays.
Jonathan H Booth, Andrew T Meek ... Malte C Gather
A new optical approach reveals dynamics of ground reaction forces in Drosophila larvae and opens new avenues for studying the biomechanics of movement in small animals.
The termination of medulla neuroblasts is specified by the depletion of the neuroepithelium and mediated by apoptosis, differentiation, and gliogenic switch.
Noémie te Rietmolen, Manuel R Mercier ... Daniele Schön
The neural response to natural speech and music processing is mostly shared between the domains, with additional evidence for selectivity in distributed (i.e. not regional) and frequency-specific neural activity.
N Suhas Jagannathan, Javier Yu Peng Koh ... Lisa Tucker-Kellogg
To investigate why bats are long-lived and cancer-resistant, multi-omic data from bat and human cells was analyzed using computational flux modeling, suggesting dysregulation of succinate-fumarate dynamics and an ischemic-like basal metabolism in bat cells.
