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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification

    Nikola Sekulovski, Jenna C Wettstein ... Kenichiro Taniguchi
    Analyses of transcriptomic dynamics in a new model of human amnion formation identify five continuous amniogenic transcriptional phases as well as a critical role of TFAP2A in amnion fate progression.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Human adherent cortical organoids in a multiwell format

    Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

    Bethany Moyse, Joanna Moss ... Rebecca J Richardson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Shared structure facilitates working memory of multiple sequences

    Qiaoli Huang, Huan Luo
    Common cognitive maps across feature dimensions are spontaneously leveraged to facilitate storage of multiple sequences via compressed encoding and neural replay in human working memory.
    1. Ecology

    Landing force reveals new form of motion-induced sound camouflage in a wild predator

    Kim Schalcher, Estelle Milliet ... Emily LC Shepard
    Bio-logging reveals that barn owls enhance hunting success by using man-made poles to silently approach their prey, emphasizing a link between predator-prey interactions and land-use in the agricultural landscape.
    1. Cancer Biology

    YAP/TAZ enhances P-body formation to promote tumorigenesis

    Xia Shen, Xiang Peng ... Chen-Ying Liu
    P-body is a new downstream effector of YAP/TAZ for tumorigenesis and tumor progression, suggesting disruption of P-bodies as a potential therapeutic strategy for tumors with active YAP.
    1. Plant Biology

    Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

    Yaning Cui, Hongping Qian ... Jinxing Lin
    The phosphorylation of FLS2 may activate flg22-triggered immunity by facilitating the partitioning of FLS2 into functional AtRem1.3-associated nanodomains.
    Version of Record
    Short Report
    • Important
    • Solid
    1. Microbiology and Infectious Disease

    Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination

    Hideo Fukuhara, Kohei Yumoto ... Katsumi Maenaka
    X-ray crystallographic and atomic force microscopic analyses reveal the tilted homodimer structure and unanticipated dynamic characteristics of canine distemper virus-hemagglutinin (CDV-H), providing insights into the molecular and dynamic processes of Morbillivirus for cell entry, effective immunizations, and vaccine/drug design.
    1. Neuroscience

    Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction

    Sophie Peterson, Amanda Maheras ... Ronald Keiflin
    Rodent model of context-dependent discrimination reveals sex-biased tradeoff between speed of acquisition and robustness of contextual control over cue-elicited reward seeking, linked to orbitofrontal cortex activation.
    1. Cell Biology
    2. Neuroscience

    Presynaptic Rac1 in the hippocampus selectively regulates working memory

    Jaebin Kim, Edwin Bustamante ... Scott H Soderling
    Presynaptic Rac1 inhibition in the hippocampus impairs spatial working memory, potentially by modulating the synaptic cytoskeleton and kinase-mediated phosphorylation of key synaptic vesicle proteins.