Christin Krause, Jan H Britsemmer ... Henriette Kirchner
The liver microRNA transcriptome of humans with type 2 diabetes and obesity is analyzed for the first time and compared with diet-induced obesity in mice.
Brain-machine interfacing was used to align trials with heightened prefrontal-hippocampal oscillatory synchronization on spatial working memory-dependent and -independent tasks, and these trials were associated with correct choices.
Adaptation within a continuous attractor neural network explains theta phase precession and procession, providing insight into the neural mechanism of theta phase coding in the hippocampus.
Behavioral and circuit analyses show that changes to energetic demand are a key driver of consolidation of daily sleep and feeding patterns as animals mature.
Katarzyna Marta Zoltowska, Utpal Das ... Lucía Chávez-Gutiérrez
A novel Aβ-driven inhibitory mechanism on γ-secretases, which leads to substrate accumulation and reduced release of products, contributes to neurotoxicity by impairing γ-secretase signaling and might operate in Alzheimer’s disease.
Nicholas GW Kennedy, Jessica C Lee ... Nathan M Holmes
When new and past experiences are similar, the memories of those experiences are stored together, and when new and past experiences are different, the memories of those experiences are stored separately.
Sara Ibañez, Nilapratim Sengupta ... Christina M Weaver
Biologically plausible levels of myelin dystrophy induce substantial working memory impairment in a computational model of brain aging across two spatial and temporal scales.
