A local-ancestry-aware association model identified a suggestive association peak within the HLA class II region linked to TB in a complex, highly admixed Southern African population.
JeYoung Jung, Steve Williams, Matthew A Lambon Ralph
GABAergic inhibition in the anterior temporal lobe shapes semantic memory and its neuroplasticity through a non-linear relationship, revealing a neurochemical basis for individual differences.
Drug synergy Interaction Prediction improves personalized drug synergy prediction by utilizing drug-specific pathway activation scores to predict personalized drug synergy and reveals mechanistic pathways underlying synergistic effects.
Functional analyses reveal the HNF4α-TET2-FBP1 axis as a critical regulator of gluconeogenesis, type 2 diabetes (T2D) progression, and metformin’s therapeutic effects, which proposes TET2 as a promising therapeutic target for T2D.
The drug-phospholipid interaction is fully elucidated at molecular level as an important part of the mode of action of daptomycin and the mechanism of its resistance in bacterial pathogens.
