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Page 449 of 1,892
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques

    Charlotte Rimbault, Christelle Breillat ... Matthieu Sainlos
    Engineering new intrabodies allows to develop selective and non-interfering tools for the visualization of endogenous PSD-95 with advanced imaging techniques.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Deep Batch Active Learning for Drug Discovery

    Michael Bailey, Saeed Moayedpour ... Sven Jager
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience
    2. Computational and Systems Biology

    Inter-regional delays fluctuate in the human cerebral cortex

    Joon-Young Moon, Kathrin Müsch ... Christopher J. Honey
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Physics of Living Systems

    Free volume theory explains the unusual behavior of viscosity in a non-confluent tissue during morphogenesis

    Rajsekhar Das, Sumit Sinha ... D Thirumalai
    Theoretical explanation and a novel mechanism are given for the observation that viscosity of embryonic non-confluent tissue shows glass-like behavior till a critical cell density and saturates at higher densities.
    1. Genetics and Genomics
    2. Medicine

    Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

    Dylan C Sarver, Jean Garcia-Diaz ... G William Wong
    Mice lacking Tmem263 are dwarfs, and this phenotype is associated with reduced hepatic growth hormone (GH) receptor expression, a deficit in GH-induced signaling, and low insulin-like growth factor 1 level.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genetic basis of Arabidopsis thaliana responses to infection by naïve and adapted isolates of turnip mosaic virus

    Anamarija Butkovic, Thomas James Ellis ... Santiago F Elena
    Arabidopsis lines were screened for resistance to TuMV, identifying a region on chromosome 2 linked to necrosis that includes an antiviral gene.
    1. Computational and Systems Biology

    Analysis of NIH K99/R00 awards and the career progression of awardees

    Nicole C Woitowich, Sarah R Hengel ... Daniel J Tyrrell
    There is a significant disadvantage to receive a major grant (i.e., R01) for K99/R00 awardees that are women, those at lower funded institutions, and those with lower career mobility.
    1. Neuroscience

    Implications of variable synaptic weights for rate and temporal coding of cerebellar outputs

    Shuting Wu, Asem Wardak ... Wade G Regehr
    Purkinje cell inputs onto cerebellar nuclei (CbN) neurons have highly variable strengths, which allow them to influence CbN firing in a graded manner, with the largest individual inputs effectively regulating both the rate and spike timing of CbN neuron firing.
    1. Chromosomes and Gene Expression

    Regulation of chromatin architecture by transcription factor binding

    Stephanie Portillo-Ledesma, Suckwoo Chung ... Tamar Schlick
    The binding of transcription factors to mesoscale chromatin fibers leads to microdomains whose features are dependent on the linker DNA length, linker histone density, and tail acetylation levels.
    1. Neuroscience

    Acetylcholine modulates the precision of prediction error in the auditory cortex

    David Pérez-González, Ana Belén Lao-Rodríguez ... Manuel S Malmierca
    Acetylcholine plays a multifold role in modulating neuronal mismatch in auditory cortex, affecting the precision of prediction error signaling and gating prediction errors to hierarchically higher processing levels.