Toll-like receptors (TLRs) shape trained immunity, balancing infection responses and chronic inflammation, and TLR agonists are promising immunomodulators for infectious diseases and cancer.
Lucas Fuentes Valenzuela, Paul Francois, Jan M Skotheim
Coarse-grained models of cellular growth and high-throughput empirical genetic data support the Product neutrality function in which a double-mutant fitness is the product of single-mutant fitnesses.
Climbing fiber activity gates the acquisition phase of motor learning but becomes nonessential for memory consolidation or performance once proficiency is achieved.
Amy K Webster, John H Willis ... Patrick C Phillips
Differences among genetically identical individuals can be explained using expression levels of just a handful of genes, suggesting that environmental variation can be functionally analyzed.
