Microbiology and Infectious Disease

Latest articles

1. 1. Microbiology and Infectious Disease

   Multidimensional in vitro assay for antimalarial combination testing and pharmacodynamic modeling – the MULT-i² assay

   Angela Hellingman, Christin Gumpp ... Matthias Rottmann
2. 1. Microbiology and Infectious Disease

   An abundant merozoite surface protein of Plasmodium falciparum modulates susceptibility to inhibitory antibodies

   Isabelle G Henshall, Jill Chmielewski ... Danny W Wilson

   Pathogens can use surface proteins to limit immune responses, and the finding that merozoite surface protein 2 has this property could help in Plasmodium falciparum malaria vaccine development.
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

   Kely Catarine Matteucci, Nathalia PS Leite ... Ricardo T Gazzinelli

   TNF-driven metabolic reprogramming enhances glucose utilization in monocytes through inducible nitric oxide synthase (iNOS) and hypoxia-inducible factor 1α (HIF-1α), promoting parasite control and host resistance during Plasmodium infection.
4. 1. Microbiology and Infectious Disease

   Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of Listeria monocytogenes

   Sandra Freier, Sarah Frentzel ... Sven Halbedel
5. 1. Cell Biology
   2. Microbiology and Infectious Disease

   Enteropathogenic Escherichia coli-mediated fast and coordinated Ca^²+ responses regulate NF-κB activation

   Fangrui Guo, Roberto Ornelas Guevara ... Guy Tran Van Nhieu

   Through low levels of extracellular ATP, EPEC induces small, rapid and coordinated Ca²⁺ responses in epithelial cells, a yet unreported pattern, that down-regulate inflammation at the onset of infection.
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Distinct prokaryotic gut microbiome and proviral-immune axes of pathophysiology in Sickle Cell Disease

   Zachary N Flamholz, Jennifer De Los Santos ... Libusha Kelly
7. 1. Cell Biology
   2. Microbiology and Infectious Disease

   A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by Mycobacterium tuberculosis

   Surbhi Verma, Shweta Thakur ... Dhiraj Kumar
8. 1. Microbiology and Infectious Disease

   Unexpected plasticity in the life cycle of Trypanosoma brucei

   Carina Praisler, Jaime N Lisack ... Markus Engstler
9. 1. Evolutionary Biology
   2. Microbiology and Infectious Disease

   The adaptive landscapes of three global Escherichia coli transcriptional regulators

   Cauã Antunes Westmann, Leander Goldbach, Andreas Wagner

   Across three global Escherichia coli regulators, identical starting sequences can evolve toward many distinct strong-binding peaks, with chance, historical contingency, and evolutionary bias shaping which outcomes prevail.
10. 1. Microbiology and Infectious Disease

    Reactive oxygen detoxification contributes to Mycobacterium abscessus antibiotic survival

    Nicholas A Bates, Ronald Rodriguez ... Bennett H Penn

    Antibiotics that inhibit translation cause a burst in reactive oxygen species, and these must be detoxified by factors such as KatG for cells to survive.